Browse our Smooth Muscle Actin Proteins (ACTA2)

Full name:
Actin, alpha 2, Smooth Muscle, Aorta Proteins (ACTA2)
On www.antibodies-online.com are 11 Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) Proteins from 6 different suppliers available. Additionally we are shipping Smooth Muscle Actin Antibodies (274) and Smooth Muscle Actin Kits (29) and many more products for this protein. A total of 321 Smooth Muscle Actin products are currently listed.
Synonyms:
0610041G09Rik, a-SMA, AAT6, ACT-4, ACTA2, actc1, ACTSA, Actvs, alphaSMA, asma, MYMY5, sm-actin, SMactin, SMalphaA, wu:fb63d03
list all proteins Gene Name GeneID UniProt
ACTA2 59 P62736
ACTA2 11475 P62737
ACTA2 81633 P62738

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Smooth Muscle Actin Proteins (ACTA2) by Origin

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Top referenced Smooth Muscle Actin Proteins

  1. Human Smooth Muscle Actin Protein expressed in Escherichia coli (E. coli) - ABIN1098398 : Regalado, Medrek, Tran-Fadulu, Guo, Pannu, Golabbakhsh, Smart, Chen, Shete, Kim, Stern, Braverman, Milewicz: Autosomal dominant inheritance of a predisposition to thoracic aortic aneurysms and dissections and intracranial saccular aneurysms. in American journal of medical genetics. Part A 2011 (PubMed)
    Show all 2 references for 1098398

More Proteins for Smooth Muscle Actin Interaction Partners

Xenopus laevis Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) interaction partners

  1. Data show that the locomotion and blebbing of the primordial germ cells (PGCs) required F-actin, myosin II activity and RhoA/Rho-associated protein kinase (ROCK) signaling.

Human Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) interaction partners

  1. Cells in high glucose for 7 days showed a significant decrease in mRNA expression of CD31 (show HBA1 Proteins) and VE-cadherin (show CDH5 Proteins), and a significant increase in that of alpha-SMA (show SMN1 Proteins) and collagen I.

  2. ACTA2 is the isoform of contractile protein (show TNNT2 Proteins) alpha-actin present in vascular smooth muscle cells (SMCs) throughout the arterial tree.4 Pathologic conditions in individuals with ACTA2 mutations show increased deposition of SMCs in the intimal arterial layer, leading to a decreased intraluminal diameter.4

  3. Two novel actin alpha 2 mutations (N117I and L348R) were identified in each familial non-syndromatic thoracic aortic aneurysm proband separately, and an additional novel actin alpha 2 mutation (Y168N) was identified in one patient with sporadic non-syndromatic thoracic aortic aneurysm.

  4. The R179H mutation has the potential to affect actin structure and function in both the contractile domain of the cell and the more dynamic cytoskeletal pool of actin, both of which are required for contraction.

  5. site-directed mutagenesis revealed several basic amino acid residues in the intermolecular (R267) and intramolecular (K82 and R159) subdomains that are essential for Purbeta (show PURB Proteins) transcriptional repressor function in Acta2 promoter-reporter assays. In keeping with their diminished Acta2 repressor activity in fibroblasts, purified Purbeta (show PURB Proteins) variants containing an R267A mutation exhibited reduced binding affinity for purine-ric (show FXYD5 Proteins)...

  6. Data show that the expression profiles of three proteins: E-cadherin (show CDH1 Proteins), Snail (show SNAI1 Proteins), and alpha-smooth muscle actin (show ACTG2 Proteins) were significantly different in extraprostatic extension prostate cancer (PCa (show FLVCR1 Proteins)) compared with intra-prostatic tumour.

  7. ACTA2 mutations are associated with structural disruption and functional impairment of contractile proteins, and predispose to a variety of diffuse vascular diseases including TAAD, CAD, ischemic strokes, and Moyamoya disease. Vascular SMCs are also implicated in vascular remodeling in both physiological and pathological conditions.

  8. Parenchymal alphaSMA expression in hepatic tissue appeared to increase only among hepatitis C subjects with fibrosis 3-4.

  9. Multisystemic smooth muscle dysfunction syndrome secondary to an ACTA2 mutation.

  10. alpha-SMA expression, and MLC phosphorylation, whereas butaprost inhibited TGF-beta2-induced CPCG contraction, actin polymerization, and MLC phosphorylation.

Mouse (Murine) Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) interaction partners

  1. Gremlin1 accelerates hepatic stellate cell activation through upregulation of TGF-B1, alpha-SMA (show SMN1 Proteins), and COL1a1 (show COL1A1 Proteins) expression in a liver fibrosis disease model.

  2. Disruption of smooth muscle Acta2 increases reactive oxygen species levels, activates NF-kappaB (show NFKB1 Proteins) signaling and increases AngII receptor type I a expression.

  3. The expression levels of alpha-smooth muscle actin (show ACTG2 Proteins) (alpha-SMA (show SMN1 Proteins), a marker of fibroblast activation) in fibrotic livers were significantly higher than those in control livers.

  4. this study identifies Rac1 as a downstream target for SMA (show SMN1 Proteins) to inhibit smooth muscle cell proliferation and migration.

  5. the coordinated up-regulations of desmin (show DES Proteins) and alpha- actinin (show ACTN1 Proteins) specifically in the early stage of diastolic heart failure mouse models indicate a novel myocardial response.

  6. site-directed mutagenesis revealed several basic amino acid residues in the intermolecular (R267) and intramolecular (K82 and R159) subdomains that are essential for Purbeta (show PURB Proteins) transcriptional repressor function in Acta2 promoter-reporter assays. In keeping with their diminished Acta2 repressor activity in fibroblasts, purified Purbeta (show PURB Proteins) variants containing an R267A mutation exhibited reduced binding affinity for purine-ric (show FXYD5 Proteins)...

  7. Alpha-smooth muscle actin (show ACTG2 Proteins) protein (show ACTR3 Proteins) and mRNA are enhanced from brain blood vessels in an Alzheimer's disease animal model.

  8. Astragaloside can delay the renal fibrosis process in diabetic mice by influencing the TGF-beta (show TGFB1 Proteins)/SMADS signaling pathway and down-regulating TGF-beta1 (show TGFB1 Proteins), SMAD2 (show SMAD2 Proteins)/3, and alpha-SMA (show SMN1 Proteins) expression.

  9. The increased expressions of the cartilage-associated proteins Collagen2 and alpha-SMA (show SMN1 Proteins) during scleral chondrogenesis accompany myopia development.

  10. Results suggest that the atypical motif asparaging-cysteine-systeine Asn(17)-Cys(18)-Cys(19) is crucial for the normal surface trafficking and function of hydroxycarboxylic acid receptor 2 protein hGPR109A.

Rabbit Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) interaction partners

  1. TnT has a previously unrecognized role in forming the inactive state of regulated actin.

  2. The terminal pointed end subunit is tilted (show OTOP1 Proteins) towards the penultimate subunit, allowing specific and extra loop-to-loop inter-strand contacts between the two end subunits, which is not possible in other parts of the filament.

  3. There was no significant change in the expression of TGF-beta(2 (show TGFB2 Proteins)) and alpha-SMA (show SMN1 Proteins) after laser-assisted intrastromal scanning.

  4. The arrangement of actin subunits in an actin dimer assembled by tandem W domains resembles that of a long-pitch helix of the actin filament.

  5. The distribution of laminin and alphaSMA in the testis and epididymis might point out to their roles in the male reproduction.

Smooth Muscle Actin (ACTA2) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Alternative names and synonyms associated with Smooth Muscle Actin (ACTA2)

  • actin, alpha 2, smooth muscle, aorta (acta2)
  • actin, alpha 2, smooth muscle, aorta (ACTA2)
  • actin, alpha 2, smooth muscle, aorta (Acta2)
  • 0610041G09Rik protein
  • a-SMA protein
  • AAT6 protein
  • ACT-4 protein
  • ACTA2 protein
  • actc1 protein
  • ACTSA protein
  • Actvs protein
  • alphaSMA protein
  • asma protein
  • MYMY5 protein
  • sm-actin protein
  • SMactin protein
  • SMalphaA protein
  • wu:fb63d03 protein

Protein level used designations for ACTA2

SM actin , alpha smooth muscle actin , alpha-SM-actin , actin, alpha 2, smooth muscle, aorta , actin alpha cardiac 1 , actin, aortic smooth muscle , vascular smooth muscle alpha-actin , alpha-smooth muscle actin , actin, aortic smooth muscle-like , alpha-cardiac actin , cell growth-inhibiting gene 46 protein , actin, alpha, vascular smooth muscle , alpha-actin-2 , alpha actin 2 , alpha-actin , smooth muscle alpha-actin , alpha actin

GENE ID SPECIES
431847 Xenopus laevis
477587 Canis lupus familiaris
496696 Xenopus (Silurana) tropicalis
733615 Sus scrofa
100074413 Ornithorhynchus anatinus
100173819 Pongo abelii
466148 Pan troglodytes
100062175 Equus caballus
100396597 Callithrix jacchus
100427024 Macaca mulatta
100579983 Nomascus leucogenys
59 Homo sapiens
11475 Mus musculus
322509 Danio rerio
515610 Bos taurus
423787 Gallus gallus
100009271 Oryctolagus cuniculus
81633 Rattus norvegicus
100722917 Cavia porcellus
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