Browse our anti-ABCC8 (ABCC8) Antibodies

Full name:
anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 Antibodies (ABCC8)
On are 82 ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) Antibodies from 19 different suppliers available. Additionally we are shipping ABCC8 Proteins (7) and ABCC8 Kits (1) and many more products for this protein. A total of 94 ABCC8 products are currently listed.
ABC36, D930031B21Rik, HHF1, HI, HRINS, MRP8, PHHI, Sur, Sur1, SUR1delta2, TNDM2
list all antibodies Gene Name GeneID UniProt
ABCC8 6833 Q09428
ABCC8 20927  
ABCC8 25559 Q09429

Show all species

Show all synonyms

Most Popular Reactivities for anti-ABCC8 (ABCC8) Antibodies

Select your species and application

anti-Human ABCC8 Antibodies:

anti-Mouse (Murine) ABCC8 Antibodies:

anti-Rat (Rattus) ABCC8 Antibodies:

All available anti-ABCC8 Antibodies

Go to our pre-filtered search.

Top referenced anti-ABCC8 Antibodies

  1. Human Monoclonal ABCC8 Primary Antibody for ELISA, WB - ABIN4948191 : Jablonski, McAteer, de Bakker, Franks, Pollin, Hanson, Saxena, Fowler, Shuldiner, Knowler, Altshuler, Florez: Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. in Diabetes 2010 (PubMed)
    Show all 5 references for 4948191

  2. Human Polyclonal ABCC8 Primary Antibody for DB, EIA - ABIN493480 : Thomas, Cote, Wohllk, Haddad, Mathew, Rabl, Aguilar-Bryan, Gagel, Bryan: Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy. in Science (New York, N.Y.) 1995 (PubMed)
    Show all 3 references for 493480

  3. Hamster Monoclonal ABCC8 Primary Antibody for ICC, IF - ABIN1027723 : Campbell, Sansom, Ashcroft: Potassium channel regulation. in EMBO reports 2003 (PubMed)
    Show all 2 references for 1027723

  4. Cow (Bovine) Polyclonal ABCC8 Primary Antibody for IHC, WB - ABIN2781496 : Babenko: A novel ABCC8 (SUR1)-dependent mechanism of metabolism-excitation uncoupling. in The Journal of biological chemistry 2008 (PubMed)

  5. Human Polyclonal ABCC8 Primary Antibody for ELISA, WB - ABIN334499 : de Wet, Rees, Shimomura, Aittoniemi, Patch, Flanagan, Ellard, Hattersley, Sansom, Ashcroft: Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes. in Proceedings of the National Academy of Sciences of the United States of America 2007 (PubMed)

More Antibodies against ABCC8 Interaction Partners

Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) interaction partners

  1. Hyperinsulinism-causing mutations cause multiple molecular defects in SUR1 nucleotide-binding domains.

  2. Genes ABCC7 (show CFTR Antibodies), A3, A8, A12 (show UGT1A9 Antibodies), and C8 prevailed among the most upregulated or downregulated ones. In conclusion, the results supported our theory about general adenosine triphosphate-binding cassette gene expression profiles and their importance for cancer on clinical as well as research levels.

  3. Cross-linking experiments showed that KATP channel inhibitors promoted interactions between the N terminus of Kir6.2 and SUR1, whereas channel openers did not, suggesting the inhibitors enhance intersubunit interactions to overcome channel biogenesis and trafficking defects.

  4. Mutations of the ABCC8 gene is associated with congenital hyperinsulinism.

  5. ABCC8 mutation is associated with neonatal diabetes mellitus and iDEND syndrome.

  6. The most frequently seen mutations in Turkish patients with congenital hyperinsulinism (CHI) were ATP binding cassette subfamily C (show CYP Antibodies) member 8 (ABCC8) gene, followed by 3-hydroxyacyl CoA dehydrogenase (HADH (show HADH Antibodies)) and kcnj11 (show KCNJ11 Antibodies) channel (KCNJ11 (show KCNJ11 Antibodies)) genes.

  7. Mutations in the ABCC8 gene were the most common cause of congenital hyperinsulinism in our cohort.

  8. ABCC8 mutation is associated with persistently elevated insulin (show INS Antibodies) concentrations.

  9. A study of mutations in the ABCC8 gene that cause congenital hyperinsulinism demonstrate a clear functional distinction between SUR1 nucleotide-binding domain two (NBD2) and transmembrane domain (TMD (show TTN Antibodies)) mutants

  10. up-regulation of SUR1 in humans point to this channel as one of the important molecular players in the pathophysiology of Post-traumatic brain contusions

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) interaction partners

  1. Despite its importance in central nervous system (CNS) injuries, sulfonylurea receptor 1 (SUR1) upregulation appears to play no part in rodent anterior ischemic optic neuropathy (rAION) injury.

  2. study provides evidence for a role of Abcc8(ATP-binding cassette sub-family C) in early-phase glucose-mediated insulin (show INS Antibodies) secretion and validates this gene as a contributor to beta-cell dysfunction in type 2 diabetes

  3. We conclude that the gradual development of glucose intolerance in patients with the SUR1-E1506K mutation might, as in the mouse model, result from impaired insulin (show INS Antibodies) secretion due a failure of insulin (show INS Antibodies) content to increase with age.

  4. The results confirm that Kir6.2 (show KCNJ11 Antibodies) contributes to APD shortening in both atria and ventricle during metabolic stress, and that SUR1 is required for atrial APD shortening while SUR2A (show ABCC9 Antibodies) is required for ventricular APD shortening.

  5. EPAC (show RAPGEF3 Antibodies) interaction with SUR1 controls seizure susceptibility and possibly acts via regulation of glutamate (show GRIN1 Antibodies) release.

  6. the role of CpG methylation in regulating SUR1 and SUR2 (show ABCC9 Antibodies) expression

  7. SUR1 controls K(ATP) channel activity but not TRPM4 (show TRPM4 Antibodies) channels.

  8. Conserved intramolecular disulfide bond is critical to trafficking and fate of ATP-binding cassette (ABC (show ABCB6 Antibodies)) transporters ABCB6 (show ABCB6 Antibodies) and sulfonylurea receptor 1 (SUR1)/ABCC8.

  9. ATP regulates pancreatic beta-cell K(ATP) channel activity, not only by its direct actions on Kir6.2 pore subunit, but also via ATP modulation of Syn-1A binding to SUR1.

  10. Diazoxide does not open the ventricular sarcolemmal adenosine triphosphate-sensitive potassium channel but provides volume homeostasis via an SUR1-dependent pathway in mouse ventricular myocytes.

Pig (Porcine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) interaction partners

  1. islets express mRNA transcripts for sulfonylurea receptor 1 (Sur1), inward rectifying potassium channel (show KCNAB2 Antibodies) (Kir6.2 (show KCNJ11 Antibodies), associated with Sur1), glucagon-like peptide 1 receptor (GLP1R (show GLP1R Antibodies)), and adrenergic receptor alpha 2A (show ADRA2A Antibodies) (ADRalpha2A)

ABCC8 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed\; however, the transcript variants have not been fully described.

Alternative names and synonyms associated with ABCC8

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 8 (ABCC8) antibody
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 8 (Abcc8) antibody
  • ATP-binding cassette, subfamily C (CFTR/MRP), member 8 (Abcc8) antibody
  • ABC36 antibody
  • D930031B21Rik antibody
  • HHF1 antibody
  • HI antibody
  • HRINS antibody
  • MRP8 antibody
  • PHHI antibody
  • Sur antibody
  • Sur1 antibody
  • SUR1delta2 antibody
  • TNDM2 antibody

Protein level used designations for ABCC8

ATP-binding cassette, sub-family C (CFTR/MRP), member 8 , ATP-binding cassette, sub-family C, member 8 , ATP-binding cassette sub-family C member 8 , ATP-binding cassette transporter sub-family C member 8 , sulfonylurea receptor (hyperinsulinemia) , sulfonylurea receptor 1 , sulfonylurea receptor , sulphonylurea receptor 1

423072 Gallus gallus
451056 Pan troglodytes
654490 Macaca mulatta
6833 Homo sapiens
20927 Mus musculus
485402 Canis lupus familiaris
538996 Bos taurus
100158245 Sus scrofa
100722700 Cavia porcellus
25559 Rattus norvegicus
Selected quality suppliers for anti-ABCC8 (ABCC8) Antibodies
Did you look for something else?