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The ADD1 Gly460Trp gene polymorphism is significantly and independently associated with Essential Hypertension risk in a Caucasian population from Madeira Island.
ZNF322A (show ZNF322A ELISA Kits) overexpression transcriptionally dysregulates genes involved in cell growth and motility therefore contributes to lung tumorigenesis and poor prognosis
ADD1 rs4963 polymorphism showed an increased hypertension risk.
This indicates that ADD1 G460W polymorphism could be an important factor in the pathophysiology of tinnitus.
Study shows that ADD1-rs4963 conferred susceptibility to colorectal cancer (CRC (show CALR ELISA Kits)) suggesting an association between ADD1 and CRC (show CALR ELISA Kits) risk.
The T allele of ADD1 is associated with essential hypertension in Asians.
study of potential effects of interaction between DNA methylation (show HELLS ELISA Kits) of ADD1 promoter and ADD1 tagSNPs and environmental factors on essential hypertension (EH); results indicate ADD1 SNP rs4961 has a protective role in development of EH; interactions between alcohol consumption and DNA methylation (show HELLS ELISA Kits) of ADD1 gene promoter have a significant role in modifying EH susceptibility
There were significant differences between the control group and pediatric hypertensive group in terms of ACE (show ACE ELISA Kits) I/D (P<0.05) and AGT (show AGXT ELISA Kits) M235T (P<0.05) polymorphisms, but there were no differences in ADD Gly460Trp (P>0.05) polymorphism.
A significant association was found between ADD1 gene G614T polymorphism and essential hypertension in Chinese patients. Further studies need to be done to confirm these findings in a large sample.
When alpha-adducin complexes with sodium potassium ATPase (show DNAH8 ELISA Kits) in astrocytes, non-cell autonomous neurodegeneration is triggered.
Exposure to a xenobiotic during early development induced persistent fat accumulation via hypomethylation of lipogenic genes. Moreover, increased Nrf2 (show NFE2L2 ELISA Kits) recruitment to the Srebp-1c (show SREBF1 ELISA Kits) promoter in livers of BPA (show DST ELISA Kits)-exposed mice was observed.
Reduction in ADD1 protein in NEK1 (show NEK1 ELISA Kits) mutant mice is associated with hyperphosphorylation of ADD1, thereby preventing the interaction with MYO10 (show MYO10 ELISA Kits) during meiotic spindle formation
suggesting a specific effect of sterol regulatory element binding protein (show CNBP ELISA Kits)-1c on neurosteroidogenesis
Transforming growth factor-beta activated kinase 1 (TAK1 (show MAP3K7 ELISA Kits)) regulation of sterol-regulatory element-binding proteins (SREBPs) critically contributes to the maintenance of liver homeostasis to prevent steatosis, which is a potentially important mechanism to prevent hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)) development.
miR (show MLXIP ELISA Kits)-185 negatively regulates the differentiation of 3T3-L1 cells by targeting SREBP-1 (show SREBF1 ELISA Kits)
SREBP1 (show SREBF1 ELISA Kits) pathway plays an important role in hepatocellular carcinoma pathogenesis.
In hepatocytes, E4BP4 (show NFIL3 ELISA Kits) interacts with nuclear SREBP-1c (show SREBF1 ELISA Kits) to preserve its acetylation, and subsequently protects it from ubiquitination-dependent degradation
SREBP1 (show SREBF1 ELISA Kits) also contributes to the resolution phase of TLR4 (show TLR4 ELISA Kits)-induced gene activation by reprogramming macrophage lipid metabolism.
27OH is not an important regulator of Srebp- or LXR regulated genes under basal conditions in mouse liver
Collectively, these findings demonstrate that LXRalpha (show NR1H3 ELISA Kits) activation induces 17beta-HSD13 expression in a SREBP-1c (show SREBF1 ELISA Kits)-dependent manner.
Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms\; however, not all variants have been fully described.
adducin 1 (alpha)
, adducin 2 (beta)
, erythrocyte adducin alpha subunit
, erythrocyte adducin subunit alpha
, adipocyte determination- and differentiation-dependent factor 1
, sterol regulatory element-binding protein 1