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a heterozygous nonsense mutation in the first exon of cyclic nucleotide phosphodiesterase 8B gene, which is predicted to disrupt all important functional domains of the cyclic nucleotide phosphodiesterase 8B protein, in two members of family with autosomal-dominant striatal degeneration
Genetic variation of the PDE8B gene may be involved in the etiology of subclinical hypothyroidism in pregnant women.
A prevalence of the minor allele of PDE8B gene polymorphism associated with elevated serum levels of TSH was demonstrated in patients affected by sporadic nonautoimmune subclinical hypothyroidism.
rs4704397 in phosphodiesterase 8B is associated with thyrotropin and thyroid hormone (show PTH ELISA Kits) concentrations
There is an association between homozygous A/A as well as homozygous G/G carriers of SNP rs 4704397 in PDE8B and recurrent miscarriage.
PDE8B gene polymorphisms may be correlated with hyperthyroxinemia in the Chinese Han population.
PDE8B is another PDE (show ALDH7A1 ELISA Kits) gene in which variations may contribute to predisposition of adrenocortical tumours.
In obese children, PDE8B is associated with TSH; the interaction between adiposity and PDE8B on TSH is not synergistic, but follows an additive model.
Common genetic variation in PDE8B is associated with reciprocal changes in thyroid hormone (show PTH ELISA Kits) levels.
Our analysis revealed separate segregation of an inactivating PDE8B allele from the high-TSH-allele and showed low TSH levels in persons who carry an inactivating PDE8B allele. These data suggest that PDE8B may be involved in regulation of TSH levels.
Pde8b knockout mice demonstrate improvement in select behaviors, motor-coordination, attenuation of age-induced motor coordination decline and increased anxiety levels.
findings suggest that both PDE8A (show PDE8A ELISA Kits) and PDE8B play essential roles to maintain low cAMP levels, thereby suppressing resting steroidogenesis by keeping CEH (show EPHX2 ELISA Kits)/HSL (show LIPE ELISA Kits) inactive and StAR protein expression low
Phosphodiesterase 8B is a major regulator of pools of cyclic AMP (show TMPRSS5 ELISA Kits) that promote steroidogenesis.
The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.
, high-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
, high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B-like
, 3',5' cyclic nucleotide phosphodiesterase 8B
, cell proliferation-inducing gene 22 protein
, high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
, cAMP-specific cyclic nucleotide phosphodiesterase PDE8