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anti-Human SYTL4 Antibodies:
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Human Polyclonal SYTL4 Primary Antibody for ICC, IF - ABIN4357440
Salazar, Zlatic, Craige, Peden, Pohl, Faundez: Hermansky-Pudlak syndrome protein complexes associate with phosphatidylinositol 4-kinase type II alpha in neuronal and non-neuronal cells. in The Journal of biological chemistry 2009
Show all 2 Pubmed References
Determined the solution structure of human synaptotagmin-like protein 4 (Slp4). Through modification of cysteine residues, found Slp4 (show S1PR4 Antibodies) binding of two zinc atoms is required for correct folding.
Granuphilin makes granules immobile and fusion-reluctant beneath the plasma membrane. Those granuphilin-positive, docked granules release a portion of granuphilin upon fusion, and fuse at a frequency and time course similar to those of granuphilin-negative undocked granules. Granuphilin forms a 180-nm cluster at the site of each docked granule, along with granuphilin-interacting Rab27a (show RAB27A Antibodies) and Munc18-1 (show STXBP1 Antibodies) clusters.
GLUT5 (show SLC2A5 Antibodies) required an interaction cascade of Rab11 (show RAB11A Antibodies), Myo5B, Slp4a, Munc18-2 (show STXBP2 Antibodies), and Vamp7 (show VAMP7 Antibodies) with Stx3 (show STX3 Antibodies).
Phosphatidylinositol 4,5-bisphosphate binds to the concave surface of granuphilin-C2A domain. The key residues involved in the binding were validated by mutation analysis.
the mechanisms of granuphilin plasma membrane targeting and release
Recruitment of STXBP1 (show STXBP1 Antibodies) by the Rab27A (show RAB27A Antibodies) effector SYTL4 promotes Weibel-Palade body exocytosis.
Slp4 (show S1PR4 Antibodies) and Rab8 (show RAB8A Antibodies) are expressed and interact in human platelets, and might be involved in dense granule release.
in insulin (show INS Antibodies)-producing cells adequate levels of mir (show MLXIP Antibodies)-9 are mandatory for maintaining appropriate Granuphilin levels and optimal secretory capacity
Synaptotagmin-like protein 4 (Slp4)/granuphilin-a contains an N-terminal Slp (show SEPT9 Antibodies) homology domain (SHD (show SHD Antibodies)) (PMID: 11327731). The SHD (show SHD Antibodies) of Slp4 (show S1PR4 Antibodies) specifically and directly binds the GTP (show AK3 Antibodies)-bound form of Rab3A (show RAB3A Antibodies), Rab8 (show RAB8A Antibodies), and Rab27A (show RAB27A Antibodies).
Granuphilin and exophilin7, differentially regulate the exocytosis of either stably or minimally docked granules, respectively.
granuphilin binds to syntaxin-2 (show STX2 Antibodies) and syntaxin-3 (show STX3 Antibodies) as well as syntaxin-1a (show STX1A Antibodies), it likely mediates granule docking through interactions with those multiple syntaxins on the plasma membrane.
granuphilin promotes the plasma membrane targeting of insulin (show INS Antibodies) granules via interaction with syntaxin 1a (show STX1A Antibodies)
It is shown that the granuphilin promoter is a target of SREBP-1c (show SREBF1 Antibodies), a transcription factor that controls fatty acid synthesis, and MafA (show MAFA Antibodies), a beta (show SUCLA2 Antibodies) cell differentiation factor
Synaptotagmin-like protein 4 (Slp4)/granuphilin-a contains an N-terminal Slp (show SEPT9 Antibodies) homology domain (SHD (show SHD Antibodies)) (PMID: 11327731). The SHD (show SHD Antibodies) of Slp4 specifically and directly binds the GTP (show AK3 Antibodies)-bound form of Rab3A (show RAB3A Antibodies), Rab8 (show RAB8A Antibodies), and Rab27A (show RAB27A Antibodies).
This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein.
synaptotagmin-like 4 (granuphilin-a)
, synaptotagmin-like 4
, synaptotagmin-like protein 4
, granuphilin b