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human brain malformation is recapitulated in Arhgef2 mutant mice and identify an aberrant migration of distinct components of the precerebellar system as a pathomechanism underlying the midbrain-hindbrain phenotype. Our results highlight the crucial function of ARHGEF2 in human brain development and identify a mutation in ARHGEF2 as novel cause of a neurodevelopmental disorder.
These results identify GEF-H1 as a component of the shear stress response machinery in neutrophils required for a fully competent immune response to bacterial infection.
Study describes a new mode of GEF-H1 activation in response to G-protein-coupled receptor (GPCR (show TAS1R3 ELISA Kits)) ligands that is independent of microtubule depolymerization.
Data show that the activation of the microtubule-associated guanine nucleotide exchange factor (show ARHGEF12 ELISA Kits) GEF-H1, encoded by Arhgef2, is essential for sensing of foreign RNA by RIG-I (show DDX58 ELISA Kits)-like receptors.
Pak2 (show PAK2 ELISA Kits), but not Pak1 (show PAK1 ELISA Kits), negatively regulates RhoA (show RHOA ELISA Kits) via phosphorylation of the guanine nucleotide exchange factor (show ARHGEF12 ELISA Kits) GEF-H1 at an inhibitory site, leading to increased GEF-H1 microtubule binding and loss of RhoA (show RHOA ELISA Kits) stimulation
It was shown that the guanine exchange factors GEF-H1 and ECT2 (show ECT2 ELISA Kits) must be downregulated for megakaryote polyploidization. The first (2N-4N) endomitotic cycle requires GEF-H1 downregulation, whereas subsequent cycles (>4N) require ECT2 (show ECT2 ELISA Kits) downregulation.
CAPN6 (show CAPN6 ELISA Kits) acts as a regulator of Rac1 and cell motility through interaction with GEF-H1.
LARG is activated by the Src family tyrosine kinase Fyn, whereas GEF-H1 catalytic activity is enhanced by ERK downstream of a signalling cascade that includes FAK and Ras
p114-RhoGEF (show ARHGEF18 ELISA Kits) and Lfc are critically involved in Wnt-3a (show WNT3A ELISA Kits)- and Dvl (show DVL1 ELISA Kits)-induced RhoA (show RHOA ELISA Kits) activation and neurite retraction in N1E-115 cells.
Depletion of GEF-H1 in the murine two-hit model of VILI attenuated vascular leak induced by lung ventilation at high tidal volume and thrombin (show F2 ELISA Kits)-derived peptide TRAP6.
depletion induces phosphorylation of the microtubule-associated GEF-H1 on Ser886, and thereby promotes RhoA activity and actin stress fiber assembly.
Overexpression of miR (show MLXIP ELISA Kits)-194 downregulates the GEF-H1/RhoA (show RHOA ELISA Kits) pathway, inhibits melanoma cancer cell proliferation and metastasis. Furthermore, miR (show MLXIP ELISA Kits)-194 expression is negatively associated with tumor-node-metastasis (TNM (show ODZ1 ELISA Kits)) stages
data suggest that the induction of SGK1 (show SGK1 ELISA Kits) through treatment with dexamethasone alters MT dynamics to increase Sec5 (show EXOC2 ELISA Kits)-GEF-H1 interactions, which promote GEF-H1 targeting to adhesion sites.
this study reports the crystal structure of human GEF-H1 PH domain to 2.45 A resolution.
By stimulating cofilin (show CFL1 ELISA Kits)/PP2A (show PPP2R4 ELISA Kits)-mediated dephosphorylation of the guanine nucleotide exchange factor (show RASGRF1 ELISA Kits) GEF-H1.
regulation of c-Src trafficking requires both microtubules and actin polymerization, and GEF-H1 coordinates c-Src trafficking, acting as a molecular switch between these two mechanisms
Results supported that miR (show MLXIP ELISA Kits)-512-3p could inhibit tumor cell adhesion, migration, and invasion by regulating the RAC1 activity via DOCK3 (show DOCK3 ELISA Kits) in NSCLC A549 and H1299 cell lines.
TGF-beta (show TGFB1 ELISA Kits) regulates LARG (show ARHGEF12 ELISA Kits) and GEF-H1 during epithelial-mesenchymal transition to affect stiffening response to force and cell invasion.
Our findings underscore a potent oncogenic role for GEF-H1 in promoting the metastatic potentials of hepatocellular carcinoma, possibly through activation of RhoA (show RHOA ELISA Kits) signalling.
Data indicate that TNF-alpha (show TNF ELISA Kits) stimulates Rac (show AKT1 ELISA Kits), ADAM17/TACE (show ADAM17 ELISA Kits), and RhoA (show RHOA ELISA Kits) through the guanine nucleotide exchange factor (show ARHGEF12 ELISA Kits) (GEF)-H1.
Data indicate that GEF-H1 is a target and functional effector of TGF-beta (show TGFB1 ELISA Kits) by orchestrating Rho signaling to regulate gene expression and cell migration.
ERK/GEF-H1/Rho/ROK/pMLC pathway could be a central mechanism whereby electrogenic transmembrane transport processes control myosin phosphorylation and regulate paracellular transport in the tubular epithelium.
the ERK (show MAPK1 ELISA Kits)/GEF-H1/Rho/Rho kinase (show ROCK1 ELISA Kits)/phospho-MLC pathway is the mechanism mediating TNF-alpha (show TNF ELISA Kits)-induced elevation of tubular epithelial permeability, which in turn might contribute to kidney injury
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.
Rho/Rac guanine nucleotide exchange factor (GEF) 2
, guanine nucleotide exchange factor LFC
, Rho/Rac guanine nucleotide exchange factor 2
, rho guanine nucleotide exchange factor 2-like
, LBC'S first cousin
, guanine nucleotide exchange factor H1
, lymphoid blast crisis-like 1
, oncogene LFC
, rho guanine nucleotide exchange factor 2
, microtubule-regulated Rho-GEF
, proliferating cell nucleolar antigen p40
, Guanine nucleotide exchange factor H1
, rho/rac guanine nucleotide exchange factor 2
, tight junction-associated guanine nucleotide exchange factor