Browse our ARHGEF2 Proteins (ARHGEF2)

Full name:
rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 Proteins (ARHGEF2)
On www.antibodies-online.com are 6 rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) Proteins from 3 different suppliers available. Additionally we are shipping ARHGEF2 Antibodies (71) and ARHGEF2 Kits (5) and many more products for this protein. A total of 88 ARHGEF2 products are currently listed.
Synonyms:
AA408978, GEF, GEF-H1, GEF-H1/LFC, GEFH1, Lbcl1, Lfc, LFP40, MGC75855, MGC82333, MGC86214, mKIAA0651, P40
list all proteins Gene Name GeneID UniProt
ARHGEF2 16800 Q60875
ARHGEF2 9181 Q92974
Rat ARHGEF2 ARHGEF2 310635 Q5FVC2

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ARHGEF2 Proteins (ARHGEF2) by Origin

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More Proteins for ARHGEF2 Interaction Partners

Xenopus laevis rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) interaction partners

Mouse (Murine) rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) interaction partners

  1. human brain malformation is recapitulated in Arhgef2 mutant mice and identify an aberrant migration of distinct components of the precerebellar system as a pathomechanism underlying the midbrain-hindbrain phenotype. Our results highlight the crucial function of ARHGEF2 in human brain development and identify a mutation in ARHGEF2 as novel cause of a neurodevelopmental disorder.

  2. These results identify GEF-H1 as a component of the shear stress response machinery in neutrophils required for a fully competent immune response to bacterial infection.

  3. Study describes a new mode of GEF-H1 activation in response to G-protein-coupled receptor (GPCR (show TAS1R3 Proteins)) ligands that is independent of microtubule depolymerization.

  4. Data show that the activation of the microtubule-associated guanine nucleotide exchange factor (show ARHGEF12 Proteins) GEF-H1, encoded by Arhgef2, is essential for sensing of foreign RNA by RIG-I (show DDX58 Proteins)-like receptors.

  5. Pak2 (show PAK2 Proteins), but not Pak1 (show PAK1 Proteins), negatively regulates RhoA (show RHOA Proteins) via phosphorylation of the guanine nucleotide exchange factor (show ARHGEF12 Proteins) GEF-H1 at an inhibitory site, leading to increased GEF-H1 microtubule binding and loss of RhoA (show RHOA Proteins) stimulation

  6. It was shown that the guanine exchange factors GEF-H1 and ECT2 (show ECT2 Proteins) must be downregulated for megakaryote polyploidization. The first (2N-4N) endomitotic cycle requires GEF-H1 downregulation, whereas subsequent cycles (>4N) require ECT2 (show ECT2 Proteins) downregulation.

  7. CAPN6 (show CAPN6 Proteins) acts as a regulator of Rac1 and cell motility through interaction with GEF-H1.

  8. LARG is activated by the Src family tyrosine kinase Fyn, whereas GEF-H1 catalytic activity is enhanced by ERK downstream of a signalling cascade that includes FAK and Ras

  9. p114-RhoGEF (show ARHGEF18 Proteins) and Lfc are critically involved in Wnt-3a (show WNT3A Proteins)- and Dvl (show DVL1 Proteins)-induced RhoA (show RHOA Proteins) activation and neurite retraction in N1E-115 cells.

  10. Depletion of GEF-H1 in the murine two-hit model of VILI attenuated vascular leak induced by lung ventilation at high tidal volume and thrombin (show F2 Proteins)-derived peptide TRAP6.

Human rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) interaction partners

  1. depletion induces phosphorylation of the microtubule-associated GEF-H1 on Ser886, and thereby promotes RhoA activity and actin stress fiber assembly.

  2. human brain malformation is recapitulated in Arhgef2 mutant mice and identify an aberrant migration of distinct components of the precerebellar system as a pathomechanism underlying the midbrain-hindbrain phenotype. Our results highlight the crucial function of ARHGEF2 in human brain development and identify a mutation in ARHGEF2 as novel cause of a neurodevelopmental disorder.

  3. Overexpression of miR (show MLXIP Proteins)-194 downregulates the GEF-H1/RhoA (show RHOA Proteins) pathway, inhibits melanoma cancer cell proliferation and metastasis. Furthermore, miR (show MLXIP Proteins)-194 expression is negatively associated with tumor-node-metastasis (TNM (show ODZ1 Proteins)) stages

  4. data suggest that the induction of SGK1 (show SGK1 Proteins) through treatment with dexamethasone alters MT dynamics to increase Sec5-GEF-H1 interactions, which promote GEF-H1 targeting to adhesion sites.

  5. this study reports the crystal structure of human GEF-H1 PH domain to 2.45 A resolution.

  6. By stimulating cofilin (show CFL1 Proteins)/PP2A (show PPP2R4 Proteins)-mediated dephosphorylation of the guanine nucleotide exchange factor (show RASGRF1 Proteins) GEF-H1.

  7. regulation of c-Src trafficking requires both microtubules and actin polymerization, and GEF-H1 coordinates c-Src trafficking, acting as a molecular switch between these two mechanisms

  8. Results supported that miR-512-3p could inhibit tumor cell adhesion, migration, and invasion by regulating the RAC1 activity via DOCK3 in NSCLC A549 and H1299 cell lines.

  9. TGF-beta (show TGFB1 Proteins) regulates LARG (show ARHGEF12 Proteins) and GEF-H1 during epithelial-mesenchymal transition to affect stiffening response to force and cell invasion.

  10. Our findings underscore a potent oncogenic role for GEF-H1 in promoting the metastatic potentials of hepatocellular carcinoma, possibly through activation of RhoA (show RHOA Proteins) signalling.

Pig (Porcine) rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) interaction partners

  1. Data indicate that TNF-alpha (show TNF Proteins) stimulates Rac (show AKT1 Proteins), ADAM17/TACE (show ADAM17 Proteins), and RhoA (show RHOA Proteins) through the guanine nucleotide exchange factor (show ARHGEF12 Proteins) (GEF)-H1.

  2. Data indicate that GEF-H1 is a target and functional effector of TGF-beta (show TGFB1 Proteins) by orchestrating Rho signaling to regulate gene expression and cell migration.

  3. ERK/GEF-H1/Rho/ROK/pMLC pathway could be a central mechanism whereby electrogenic transmembrane transport processes control myosin phosphorylation and regulate paracellular transport in the tubular epithelium.

  4. the ERK (show MAPK1 Proteins)/GEF-H1/Rho/Rho kinase (show ROCK1 Proteins)/phospho-MLC pathway is the mechanism mediating TNF-alpha (show TNF Proteins)-induced elevation of tubular epithelial permeability, which in turn might contribute to kidney injury

ARHGEF2 Protein Profile

Protein Summary

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with ARHGEF2

  • Rho/Rac guanine nucleotide exchange factor (GEF) 2 (ARHGEF2)
  • Rho/Rac guanine nucleotide exchange factor (GEF) 2 (arhgef2)
  • Rho/Rac guanine nucleotide exchange factor 2 (LOC100346634)
  • rho/rac guanine nucleotide exchange factor (GEF) 2 (Arhgef2)
  • AA408978 protein
  • GEF protein
  • GEF-H1 protein
  • GEF-H1/LFC protein
  • GEFH1 protein
  • Lbcl1 protein
  • Lfc protein
  • LFP40 protein
  • MGC75855 protein
  • MGC82333 protein
  • MGC86214 protein
  • mKIAA0651 protein
  • P40 protein

Protein level used designations for ARHGEF2

Rho/Rac guanine nucleotide exchange factor (GEF) 2 , guanine nucleotide exchange factor LFC , Rho/Rac guanine nucleotide exchange factor 2 , rho guanine nucleotide exchange factor 2-like , LBC'S first cousin , guanine nucleotide exchange factor H1 , lymphoid blast crisis-like 1 , oncogene LFC , rho guanine nucleotide exchange factor 2 , rhobin , microtubule-regulated Rho-GEF , proliferating cell nucleolar antigen p40 , GEF-H1 , Guanine nucleotide exchange factor H1 , rho/rac guanine nucleotide exchange factor 2 , tight junction-associated guanine nucleotide exchange factor

GENE ID SPECIES
100057582 Equus caballus
398353 Xenopus laevis
407848 Xenopus (Silurana) tropicalis
457378 Pan troglodytes
719369 Macaca mulatta
100346634 Oryctolagus cuniculus
100434709 Pongo abelii
100601565 Nomascus leucogenys
16800 Mus musculus
9181 Homo sapiens
310635 Rattus norvegicus
403498 Canis lupus familiaris
100145887 Sus scrofa
505940 Bos taurus
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