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RIPK1 Proteins

(Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))
Serine-threonine kinase which transduces inflammatory and cell-death signals (necroptosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necroptosis-inducing complex.
RIPK1 Protein (AA 1-671) (GST tag) RIPK1 Protein (AA 1-671) (GST tag) RIPK1 Protein (AA 1-671) (GST tag) (ABIN1318108)

RIPK1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA

RIPK1 Protein (AA 292-438) (His tag) RIPK1 Protein (AA 292-438) (His tag) RIPK1 Protein (AA 292-438) (His tag) (ABIN7124799)

RIPK1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA

RIPK1 Protein (AA 562-671) (GST tag) RIPK1 Protein (AA 562-671) (GST tag) RIPK1 Protein (AA 562-671) (GST tag) (ABIN1318110)

RIPK1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA

RIPK1 Proteins by Grade

Find RIPK1 Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

RIPK1 Proteins by Origin

Find RIPK1 Proteins for a variety of species such as anti-Human RIPK1, anti-Bryonia dioica (Red bryony) RIPK1, anti-Drimia maritima (Sea squill) (Charybdis maritima) RIPK1. The species listed below are among those available. Click on a link to go to the corresponding products.

RIPK1 Proteins by Source

Here you will find RIPK1 Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

RIPK1 Proteins by Protein Type

Here you can find RIPK1 Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

RIPK1 Proteins by Application

Find RIPK1 Proteins validated for a specific application such as SDS, WB, ELISA, PC. Some of the available applications are listed below. Click on a link to go to the corresponding products.

RIPK1 Proteins by Biological Activity

Find RIPK1 Proteins with a specific Biological Activity. The Biological Activity listed below are among those available. Click on a link to go to the corresponding products.

Popular RIPK1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (2)
  • (1)
Cat. No. ABIN1318108
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7124799
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1318110
Quantity 2 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3095020
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3135313
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
Cat. No. ABIN5509127
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7407070
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7407073
Quantity 100 μg
Datasheet Datasheet
Reactivity Drimia maritima (Sea squill) (Charybdis maritima)
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5710700
Quantity 100 μg
Datasheet Datasheet
Reactivity Bryonia dioica (Red bryony)
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5710918
Quantity 100 μg
Datasheet Datasheet
Reactivity Momordica charantia (Bitter gourd) (Balsam pear)
Source Yeast
Validations
  • (1)
Cat. No. ABIN5714046
Quantity 100 μg
Datasheet Datasheet
Reactivity Drimia maritima (Sea squill) (Charybdis maritima)
Source Yeast
Validations
  • (1)
Cat. No. ABIN5713982
Quantity 100 μg
Datasheet Datasheet
Reactivity Bryonia dioica (Red bryony)
Source Yeast
Validations
  • (1)
Cat. No. ABIN5714110
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN2751278
Quantity 5 applications
Datasheet Datasheet

Latest Publications for our RIPK1 Proteins

Boutaffala, Bertrand, Remouchamps, Seleznik, Reisinger, Janas, Bénézech, Fernandes, Marchetti, Mair, Ganeff, Hupalowska, Ricci, Becher, Piette, Knolle, Caamano, Vandenabeele, Heikenwalder, Dejardin: "NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis." in: Cell death and differentiation, Vol. 22, Issue 12, pp. 2020-33, (2015) (PubMed).

Fuller, Osborne, Leonard, Hardyman, Vaniotis, Allen, Sugden, Clerk: "Cardiac protein kinases: the cardiomyocyte kinome and differential kinase expression in human failing hearts." in: Cardiovascular research, Vol. 108, Issue 1, pp. 87-98, (2015) (PubMed).

Aliases for RIPK1 Proteins

receptor interacting serine/threonine kinase 1 (RIPK1) Proteins
receptor (TNFRSF)-interacting serine-threonine kinase 1 (Ripk1) Proteins
receptor interacting serine/threonine kinase 1 (Ripk1) Proteins
receptor interacting serine/threonine kinase 1 L homeolog (ripk1.L) Proteins
D330015H01Rik Proteins
Rinp Proteins
RIP Proteins
RIP1 Proteins
Rip1 Proteins
rip1 Proteins
ripk1 Proteins
xrip1 Proteins
xRIP1beta Proteins
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