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Human Polyclonal NEDD4L Primary Antibody for EIA, WB - ABIN953641
Zhou, Kabra, Olson, Piper, Snyder: Hrs controls sorting of the epithelial Na+ channel between endosomal degradation and recycling pathways. in The Journal of biological chemistry 2010
Show all 3 references for ABIN953641
Cow (Bovine) Polyclonal NEDD4L Primary Antibody for WB - ABIN2774731
Raikwar, Thomas: Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel. in American journal of physiology. Renal physiology 2008
USP36 (show USP36 Antibodies) actions extend beyond TrkA (show NTRK1 Antibodies) because the presence of USP36 (show USP36 Antibodies) interferes with Nedd4-2-dependent Kv7.2 (show KCNQ2 Antibodies)/3 channel regulation.
NEDD4L negatively regulates PIK3CA (show PIK3CA Antibodies) protein levels via ubiquitination and is required for the maintenance of PI3K (show PIK3CA Antibodies)-AKT (show AKT1 Antibodies) signaling pathway.
overexpression of miR (show MLXIP Antibodies)-93 in lung cancer cells promoted TGF-b-induced EMT (show ITK Antibodies) through downregulation of NEDD4L. The analysis of publicly available gene expression array datasets indicates that low NEDD4L expression correlates with poor outcomes among patients with lung cancer, further supporting the oncogenic role of miR (show MLXIP Antibodies)-93 in lung tumorigenesis and metastasis.
the regulation of Nedd4L protein expression may play a role in the development of ovarian cancers.
Propose regulation of placental SNAT2 (show SLC38A2 Antibodies)/LAT1 (show LAT Antibodies) ubiquitination by mTORC1 and Nedd4-2.
Overexpression of Nedd4-2 enhanced hOAT4 (show SLC22A9 Antibodies) ubiquitination, and inhibited hOAT4 (show SLC22A9 Antibodies) transport activity.
Our results suggest that three screened NEDD4-2 variants do not play a leading role in the pathogenesis of photosensitive epilepsy in the Turkish population.
The mechanisms of activation and degradation of the NEDD4L:the transition from the closed to the active form is regulated by a competition of inositol 1,4,5-trisphosphate and Ca2 (show CA2 Antibodies)+.
Data show that membrane protein Ndfip1 recruits E3 ubiquitin (Ub) ligase Nedd4-2 to the Golgi to target ether-a-go-go-related gene (hERG) channel for degradation while membrane protein Ndfip2 also mediates Nedd4-2 interaction with hERG in the Golgi.
Proteomics analysis of EV71-infected cells reveals the involvement of host protein NEDD4L in EV71 replication.
these findings suggest that regulation of Dvl (show DVL2 Antibodies) protein levels by NEDD4L is essential for convergent extension during early Xenopus embryogenesis.
Results suggest a mechanism for epithelial Na+ channel regulation in which AMP (show TMPRSS5 Antibodies)-activated kinase promotes ENaC (show SCNN1A Antibodies)-Nedd4-2 interaction, inhibiting ENaC (show SCNN1A Antibodies) by increasing Nedd4-2-dependent ENaC (show SCNN1A Antibodies) retrieval from the plasma membrane.
results indicate that AMPK (show PRKAA2 Antibodies) inhibits KCNQ1 (show KCNQ1 Antibodies) activity by promoting Nedd4-2-dependent channel ubiquitination and retrieval from the plasma membrane.
This study suggested that Nedd4-regulated PTEN (show PTEN Antibodies) is a key regulator of terminal arborization in vivo.
ENaC-beta (show SCNN1B Antibodies) regulation that occurs through IKKbeta (show IKBKB Antibodies)-dependent Nedd4-2 phosphorylation at a recognized SGK1 (show SGK1 Antibodies) and protein kinase A target site.
These results identify NKCC1 (show SLC12A2 Antibodies) as a novel target for Nedd4L-mediated down-regulation in vivo, which modulates ion and fluid transport in the distal colon together with epithelial Na(+) channel (ENaC (show SCNN1A Antibodies)).
Three epilepsy-associated missense mutations reduce neural precursor cell expressed developmentally down-regulated gene 4 (show NEDD4 Antibodies)-2 (Nedd4-2)-mediated AMPA (show GRIA3 Antibodies) receptor GluA1 (show GRIA1 Antibodies) ubiquitination.
These findings elucidate a critical role of Mdm2 (show MDM2 Antibodies)-p53 (show TP53 Antibodies)-Nedd4-2 signaling underlying the regulation of neural network synchrony and seizure susceptibility.
We identified glutamate (show GRIN1 Antibodies) receptor subunit 1 (GluA1 (show GRIA1 Antibodies)), subunit of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors as a novel substrate of Nedd4-2
The short isoform of the ubiquitin ligase (show RNF123 Antibodies) NEDD4L is a CREB (show CREB1 Antibodies) target gene in hepatocytes.
Nedd4-2-mediated ubiquitination of beta-ENaC (show SCNN1B Antibodies) leading to endocytosis and degradation of apical Na(+) channels is a key feature of hypoxia-induced inhibition of transepithelial alveolar Na(+) transport.
The first physiological evidence for an essential function of Nedd4-2 in regulating voltage-gated sodium channels in the central nervous system.
NEDD4-2 is a potent posttranslational regulator of voltage-gated sodium channels.
loss of NEDD4-2 in adult renal tubules causes a new form of mild, salt-sensitive hypertension without hyperkalemia that is characterized by upregulation of NCC (show SLC12A3 Antibodies), elevation of beta/gammaENaC (show SCNN1G Antibodies), but not alphaENaC (show SCNN1A Antibodies), and a normal Na+/K+ balance
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
E3 ubiquitin-protein ligase NEDD4-like
, E3 ubiquitin-protein ligase NEDD4-like protein
, ubiquitin-protein ligase Rsp5
, neural precursor cell expressed, developmentally down-regulated 4
, neural precursor cell expressed, developmentally down-regulated gene 4b