Browse our anti-Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) Antibodies

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anti-Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like Antibodies (NEDD4L)
On www.antibodies-online.com are 62 Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) Antibodies from 16 different suppliers available. Additionally we are shipping Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like Proteins (6) and many more products for this protein. A total of 72 Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like products are currently listed.
Synonyms:
1300012C07Rik, hNEDD4-2, NEDD4, Nedd4-2, NEDD4.2, Nedd4b, RSP5
list all antibodies Gene Name GeneID UniProt
NEDD4L 23327 Q96PU5
NEDD4L 291553  
NEDD4L 83814  

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Top referenced anti-Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like Antibodies

  1. Human Polyclonal NEDD4L Primary Antibody for EIA, WB - ABIN953641 : Zhou, Kabra, Olson, Piper, Snyder: Hrs controls sorting of the epithelial Na+ channel between endosomal degradation and recycling pathways. in The Journal of biological chemistry 2010 (PubMed)
    Show all 3 references for 953641

  2. Cow (Bovine) Polyclonal NEDD4L Primary Antibody for WB - ABIN2774731 : Raikwar, Thomas: Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel. in American journal of physiology. Renal physiology 2008 (PubMed)

More Antibodies against Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like Interaction Partners

Human Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) interaction partners

  1. both Nedd4-1 (show NEDD4 Antibodies) and Nedd4-2 are important regulators for hOAT1 (show SLC22A6 Antibodies) ubiquitination, expression, and function

  2. USP36 (show USP36 Antibodies) actions extend beyond TrkA (show NTRK1 Antibodies) because the presence of USP36 (show USP36 Antibodies) interferes with Nedd4-2-dependent Kv7.2 (show KCNQ2 Antibodies)/3 channel regulation.

  3. NEDD4L negatively regulates PIK3CA (show PIK3CA Antibodies) protein levels via ubiquitination and is required for the maintenance of PI3K (show PIK3CA Antibodies)-AKT (show AKT1 Antibodies) signaling pathway.

  4. overexpression of miR (show MLXIP Antibodies)-93 in lung cancer cells promoted TGF-b-induced EMT (show ITK Antibodies) through downregulation of NEDD4L. The analysis of publicly available gene expression array datasets indicates that low NEDD4L expression correlates with poor outcomes among patients with lung cancer, further supporting the oncogenic role of miR (show MLXIP Antibodies)-93 in lung tumorigenesis and metastasis.

  5. the regulation of Nedd4L protein expression may play a role in the development of ovarian cancers.

  6. Propose regulation of placental SNAT2 (show SLC38A2 Antibodies)/LAT1 (show LAT Antibodies) ubiquitination by mTORC1 and Nedd4-2.

  7. Overexpression of Nedd4-2 enhanced hOAT4 (show SLC22A9 Antibodies) ubiquitination, and inhibited hOAT4 (show SLC22A9 Antibodies) transport activity.

  8. Our results suggest that three screened NEDD4-2 variants do not play a leading role in the pathogenesis of photosensitive epilepsy in the Turkish population.

  9. The mechanisms of activation and degradation of the NEDD4L:the transition from the closed to the active form is regulated by a competition of inositol 1,4,5-trisphosphate and Ca2 (show CA2 Antibodies)+.

  10. Data show that membrane protein Ndfip1 recruits E3 ubiquitin (Ub) ligase Nedd4-2 to the Golgi to target ether-a-go-go-related gene (hERG) channel for degradation while membrane protein Ndfip2 also mediates Nedd4-2 interaction with hERG in the Golgi.

Xenopus laevis Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) interaction partners

  1. these findings suggest that regulation of Dvl (show DVL2 Antibodies) protein levels by NEDD4L is essential for convergent extension during early Xenopus embryogenesis.

  2. Results suggest a mechanism for epithelial Na+ channel regulation in which AMP (show TMPRSS5 Antibodies)-activated kinase promotes ENaC (show SCNN1A Antibodies)-Nedd4-2 interaction, inhibiting ENaC (show SCNN1A Antibodies) by increasing Nedd4-2-dependent ENaC (show SCNN1A Antibodies) retrieval from the plasma membrane.

  3. results indicate that AMPK (show PRKAA2 Antibodies) inhibits KCNQ1 (show KCNQ1 Antibodies) activity by promoting Nedd4-2-dependent channel ubiquitination and retrieval from the plasma membrane.

  4. This study suggested that Nedd4-regulated PTEN (show PTEN Antibodies) is a key regulator of terminal arborization in vivo.

  5. ENaC-beta (show SCNN1B Antibodies) regulation that occurs through IKKbeta (show IKBKB Antibodies)-dependent Nedd4-2 phosphorylation at a recognized SGK1 (show SGK1 Antibodies) and protein kinase A target site.

Mouse (Murine) Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) interaction partners

  1. These results identify NKCC1 (show SLC12A2 Antibodies) as a novel target for Nedd4L-mediated down-regulation in vivo, which modulates ion and fluid transport in the distal colon together with epithelial Na(+) channel (ENaC (show SCNN1A Antibodies)).

  2. Three epilepsy-associated missense mutations reduce neural precursor cell expressed developmentally down-regulated gene 4 (show NEDD4 Antibodies)-2 (Nedd4-2)-mediated AMPA (show GRIA3 Antibodies) receptor GluA1 (show GRIA1 Antibodies) ubiquitination.

  3. USP36 (show USP36 Antibodies) actions extend beyond TrkA (show NTRK1 Antibodies) because the presence of USP36 (show USP36 Antibodies) interferes with Nedd4-2-dependent Kv7.2 (show KCNQ2 Antibodies)/3 channel regulation.

  4. These findings elucidate a critical role of Mdm2 (show MDM2 Antibodies)-p53 (show TP53 Antibodies)-Nedd4-2 signaling underlying the regulation of neural network synchrony and seizure susceptibility.

  5. We identified glutamate (show GRIN1 Antibodies) receptor subunit 1 (GluA1 (show GRIA1 Antibodies)), subunit of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors as a novel substrate of Nedd4-2

  6. The short isoform of the ubiquitin ligase (show RNF123 Antibodies) NEDD4L is a CREB (show CREB1 Antibodies) target gene in hepatocytes.

  7. Nedd4-2-mediated ubiquitination of beta-ENaC (show SCNN1B Antibodies) leading to endocytosis and degradation of apical Na(+) channels is a key feature of hypoxia-induced inhibition of transepithelial alveolar Na(+) transport.

  8. The first physiological evidence for an essential function of Nedd4-2 in regulating voltage-gated sodium channels in the central nervous system.

  9. NEDD4-2 is a potent posttranslational regulator of voltage-gated sodium channels.

  10. loss of NEDD4-2 in adult renal tubules causes a new form of mild, salt-sensitive hypertension without hyperkalemia that is characterized by upregulation of NCC (show SLC12A3 Antibodies), elevation of beta/gammaENaC (show SCNN1G Antibodies), but not alphaENaC (show SCNN1A Antibodies), and a normal Na+/K+ balance

Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) Antigen Profile

Antigen Summary

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L)

  • neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase (NEDD4L) antibody
  • NEDD4L (LOC776799) antibody
  • neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase (nedd4l) antibody
  • neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase (Nedd4l) antibody
  • neural precursor cell expressed, developmentally down-regulated gene 4-like (Nedd4l) antibody
  • 1300012C07Rik antibody
  • hNEDD4-2 antibody
  • NEDD4 antibody
  • Nedd4-2 antibody
  • NEDD4.2 antibody
  • Nedd4b antibody
  • RSP5 antibody

Protein level used designations for NEDD4L

E3 ubiquitin-protein ligase NEDD4-like , E3 ubiquitin-protein ligase NEDD4-like protein , ubiquitin-protein ligase Rsp5 , neural precursor cell expressed, developmentally down-regulated 4 , NEDD4.2 , neural precursor cell expressed, developmentally down-regulated gene 4b

GENE ID SPECIES
100054395 Equus caballus
100172429 Pongo abelii
776799 Gallus gallus
23327 Homo sapiens
399396 Xenopus laevis
510003 Bos taurus
291553 Rattus norvegicus
100512083 Sus scrofa
476189 Canis lupus familiaris
83814 Mus musculus
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