Browse our WWP2 Proteins (WWP2)

Full name:
WW Domain Containing E3 Ubiquitin Protein Ligase 2 Proteins (WWP2)
On www.antibodies-online.com are 9 WW Domain Containing E3 Ubiquitin Protein Ligase 2 (WWP2) Proteins from 6 different suppliers available. Additionally we are shipping WWP2 Antibodies (41) and WWP2 Kits (7) and many more products for this protein. A total of 67 WWP2 products are currently listed.
Synonyms:
1300010O06Rik, AA690238, AIP2, AW554328, id:ibd1121, wu:fo87e10, WWp2-like, zgc:154036
list all proteins Gene Name GeneID UniProt
WWP2 11060 O00308
Mouse WWP2 WWP2 66894 Q9DBH0
Rat WWP2 WWP2 291999  

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More Proteins for WWP2 Interaction Partners

Human WW Domain Containing E3 Ubiquitin Protein Ligase 2 (WWP2) interaction partners

  1. Describe an autoinhibitory mechanism for WWP2 ubiquitin ligase involving a linker-HECT domain interaction. This intramolecular interaction traps the HECT enzyme in its inactive state and can be relieved by linker phosphorylation.

  2. results provide evidence that WWP2 serves as a positive regulator of osteogenesis by augmenting RUNX2 (show RUNX2 Proteins) transactivation in a non-proteolytic mono-ubiquitination manner.

  3. Data suggest that elevated expression of WW domain containing E3 ubiquitin protein ligase 2 (WWP2) may play a role in facilitating the development of lung adenocarcinoma.

  4. we demonstrate that WWP2 promotes cell adhesion, invasion, and migration in liver cancer by upregulating CXCR3 (show CXCR3 Proteins) and CCR5 expression associated with the chemokine (show CCL1 Proteins) signaling pathway.

  5. WWP2 may represent a novel diagnostic marker and molecular therapeutic target for liver cancer.

  6. majority of ovarian carcinomas harbored homozygous or heterozygous deletions in WWP2 locus, and there was an inverse correlation in the expression levels between WWP2 and Notch3 (show NOTCH3 Proteins) in ovarian carcinomas

  7. Data provide evidence that the stability of Paip1 (show PAIP1 Proteins) can be regulated by ubiquitin-mediated degradation, thus highlighting the importance of WWP2 as a suppressor of translation.

  8. Results identify WWP2 as a novel p73 (show TP73 Proteins)-associated protein that ubiquitinates and degrades p73 (show TP73 Proteins).

  9. Wwp2 acts as a ubiquitin ligase of SRG3 (show SMARCC1 Proteins).

  10. WWP2-N is downregulated in stage IIIC melanoma and up-regulated in stage II/III prostate cancer, and WWP2-FL and WWP2-C overexpression is associated with early-stage breast cancer.

Mouse (Murine) WW Domain Containing E3 Ubiquitin Protein Ligase 2 (WWP2) interaction partners

  1. results provide evidence that WWP2 serves as a positive regulator of osteogenesis by augmenting RUNX2 (show RUNX2 Proteins) transactivation in a non-proteolytic mono-ubiquitination manner.

  2. Wwp2 acts as a ubiquitin ligase (show RNF123 Proteins) of SRG3 (show SMARCC1 Proteins).

  3. WWP2 negatively regulates TLR3 (show TLR3 Proteins)-mediated innate immune and inflammatory responses by targeting TRIF (show RNF138 Proteins) for ubiquitination and degradation.

  4. a number of miR (show MLXIP Proteins)-25 candidate gene targets

  5. Data show that MiR (show MLXIP Proteins)-140 is co-expressed with Wwp2-C and is activated by Sox9 (show SOX9 Proteins) to target Sp1 (show SP1 Proteins) in maintaining chondrocyte proliferation.

  6. ADAR2 (show ADARB1 Proteins) protein levels and catalytic activity are coordinately regulated in a positive manner by Pin1 (show PIN1 Proteins) and negatively by WWP2 and this may have downstream effects on the function of glutamate receptor 2 (show GRIA2 Proteins).

  7. The regulatory interaction between Sox9 (show SOX9 Proteins), Wwp2 and Med25 (show MED25 Proteins) defines the Sox9 (show SOX9 Proteins) transcriptional mechanisms of chondrogenesis in the forming palate.

  8. Studies demonstrate that Wwp2 influences craniofacial patterning through its interactions with Goosecoid (Gsc (show GSC Proteins)).

  9. Wwp2-mediated Oct4 (show POU5F1 Proteins) poly-ubiquitination and its auto-ubiquitination occur through the Lys (show LYZ Proteins) 63 linkage and may be involved in down-regulation of Oct4 (show POU5F1 Proteins) protein levels.

  10. These results indicate that Wwp2 plays an important role in regulating expression of Rpb1 in normal physiological conditions.

WWP2 Protein Profile

Protein Summary

This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10.

Alternative names and synonyms associated with WWP2

  • WW domain containing E3 ubiquitin protein ligase 2 (WWP2)
  • WW domain containing E3 ubiquitin protein ligase 2 (wwp2)
  • WW domain containing E3 ubiquitin protein ligase 2 (Wwp2)
  • 1300010O06Rik protein
  • AA690238 protein
  • AIP2 protein
  • AW554328 protein
  • id:ibd1121 protein
  • wu:fo87e10 protein
  • WWp2-like protein
  • zgc:154036 protein

Protein level used designations for WWP2

NEDD4-like E3 ubiquitin-protein ligase WWP2 , WW domain-containing protein 2 , WW domain containing E3 ubiquitin protein ligase 2 , atrophin-1 interacting protein 2 , WW domain-containing protein 4

GENE ID SPECIES
705464 Macaca mulatta
100038252 Xenopus (Silurana) tropicalis
100067291 Equus caballus
100561726 Anolis carolinensis
564527 Danio rerio
415868 Gallus gallus
11060 Homo sapiens
479672 Canis lupus familiaris
512457 Bos taurus
66894 Mus musculus
291999 Rattus norvegicus
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