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loss of Che-1 (show BCHE Proteins) inhibits proliferation and promotes apoptosis in MG-63 cells by decreasing the level of mutant p53 (show TP53 Proteins)
It was concluded that PARP-1 (show PARP1 Proteins) was involved in the DNA damage repair induced by HQ via increasing the accumulation of apoptosis antagonizing transcription factor through PARylation.
These results confirm Che-1 as an important regulator of p53 activity and suggest Che-1 to be a promising yet attractive drug target for cancer therapy.
In the face of high glucose threat, mitochondrial UCP2 (show UCP2 Proteins) gene expression is regulated by miR (show MLXIP Proteins)-2909 and AATF.
This mutant AATF along with its interactome consisting of SP1 (show PSG1 Proteins), DNMT3B (show DNMT3B Proteins) and Par-4 (show PAWR Proteins) ensures cancer cell DNA methylation (show HELLS Proteins) required for down-regulation of tumor suppressor genes.
HIPK2 depletion strongly decreases Che-1 ubiquitylation and degradation.
Che-1 (show BCHE Proteins) expression correlates with the progression of multiple myeloma and is required for cell growth and survival.Che-1 controls mTOR (show FRAP1 Proteins) through the induction of Redd1 (show DDIT4 Proteins) and Deptor (show DEPTOR Proteins), two important repressors of mTOR (show FRAP1 Proteins).
Cell proliferation decreased by 41% which was accompanied by apoptosis induction in 30% MCF-7 cells after AATF gene knockdown.
Che-1 (show BCHE Proteins) depletion abolishes the ability of Chk1 (show CHEK1 Proteins) to bind pericentrin and to localize at centrosomes, which, in its turn, deregulates the activation of centrosomal cyclin B-Cdk1 (show CDK1 Proteins) and advances entry into mitosis.
These results identify AATF as a nucleolar-confined c-Jun (show JUN Proteins) cofactor whose expression levels and spatial distribution determine the stress-induced activity of c-Jun (show JUN Proteins) and the levels of c-Jun (show JUN Proteins)-mediated apoptosis.
AATF is an endogenous antagonist of Par-4 (show F2RL3 Proteins) activity and an effective inhibitor of aberrant amyloid beta 1-42 production and secretion under apoptotic conditions.
Che-1 as a new Pin1 (show PIN1 Proteins) and HDM2 target and confirm its important role in the cellular response to DNA damage.
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.
apoptosis antagonizing transcription factor
, protein AATF
, Apoptosis antagonizing transcription factor
, protein AATF-like
, apoptosis-antagonizing transcription factor
, rb-binding protein Che-1
, traube protein