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our results demonstrated that miR (show MLXIP ELISA Kits)-30a may modulate the radiosensitivity of non-small cell lung cancer (NSCLC) through reducing the function of ATF1 in phosphorylation of ATM (show ATM ELISA Kits) and have potential therapeutic value.
genetic association studies in a population in China: Data suggest that an SNP in ATF1 (rs11169571) is associated with essential hypertension in the population studied; altered binding of microRNA-1283 appears to be involved.
EWSR1 (show EWSR1 ELISA Kits)-ATF1 fusion gene was found in hyalinizing clear cell carcinoma
Heme activates the ATF1 pathway in human macrophages via AMPK (show PRKAA1 ELISA Kits), and that a similar response occurs after treatment of cells with metformin.
ATF1 protein expression was significantly lower in colorectal cancer tissues than corresponding normal tissues; patients with higher ATF1 expression levels have a significantly higher survival rate than those with lower expression
Review: discuss clinicopathologic and molecular features of group of neoplasms unified by the presence of EWSR1 (show EWSR1 ELISA Kits)-CREB1 (show CREB1 ELISA Kits) and EWSR1 (show EWSR1 ELISA Kits)-ATF1 genetic fusions.
ATF-1 mediates HO-1 (show HMOX1 ELISA Kits) induction by heme and drives macrophage adaptation to intraplaque hemorrhage.
Hyalinizing clear-cell carcinoma is a unique low-grade salivary carcinoma that consistently harbors EWSR1 (show EWSR1 ELISA Kits)-ATF1 fusion.
Differential expression of CREB (show CREB1 ELISA Kits)/ATF transcription factors could be observed on neurogenic induction, pointing to a decisive role of the cAMP-CREB (show CREB1 ELISA Kits)/ATF system.
An increase in phosphorylation of CREB (show CREB1 ELISA Kits)/ATF-1 in human dental pulp cells was noted after exposure to PGF2alpha for 1-20 min,with a maximal induction at 10 min.
the HSF1 (show HSF1 ELISA Kits) complex, including BRG1 (show SMARCA4 ELISA Kits) and lysine acetyltransferases p300 (show NOTCH1 ELISA Kits) and CREB-binding protein (CBP (show CREBBP ELISA Kits)), is formed in a manner dependent on the phosphorylation of ATF1
conclude that HO-1 (show HMOX1 ELISA Kits) regulates DC maturation and function by modulating the p38 MAPK (show MAPK14 ELISA Kits)-CREB (show CREB1 ELISA Kits)/ATF1 signaling axis
Dehydroepiandrosterone sulfate (DHEAS (show SULT2A1 ELISA Kits))-induced signaling is mediated through interaction with a membrane-bound G-protein-coupled receptor (show GPR34 ELISA Kits), since silencing of Gnalpha11 leads to the abolition of the DHEAS (show SULT2A1 ELISA Kits)-induced stimulation of Erk1/2 (show MAPK1/3 ELISA Kits), ATF-1, and CREB (show CREB1 ELISA Kits).
indicate that dysregulation of p38 MAPK (show MAPK14 ELISA Kits)-CREB (show CREB1 ELISA Kits)/ATF1 signaling axis underlies the altered function and phenotype in Nrf2 (show NFE2L2 ELISA Kits)-deficient DCs
Forced expression of EWS/ATF1 resulted in the development of EWS/ATF1-dependent sarcomas. Lineage-tracing experiments indicated that neural crest-derived cells were subject to EWS/ATF1-driven transformation.
miR (show MLXIP ELISA Kits)-34c functions, at least partially, by targeting the ATF1 gene in germ cell apoptosis, providing a novel mechanism with involvement of miRNA in the regulation of germ cell apoptosis.
ATF1 is a novel substrate of RSK2 (show RPS6KA3 ELISA Kits) and that RSK2 (show RPS6KA3 ELISA Kits)-ATF1 signaling plays an important role in EGF (show EGF ELISA Kits)-induced neoplastic cell transformation.
study demonstrates a role for trophic signaling and constitutive activation of activating transcription factor 1(Atf1) and cAMP response element-binding protein (CREB (show CREB ELISA Kits)) at the time of zygotic genome activation
MSK1 (show RPS6KA5 ELISA Kits) and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB (show CREB1 ELISA Kits) and ATF1 in fibroblasts.
phosphorylation by the ERK MAPK (show MAPK1 ELISA Kits) pathway is required for epidermal growth factor (show EGF ELISA Kits)-induced c-jun (show JUN ELISA Kits) expression
Data indicate increasing expression for CREB (show CREB1 ELISA Kits), ATF1, and ATF3 (show ATF3 ELISA Kits) during gastrulation.
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.
activating transcription factor 1
, cyclic AMP-dependent transcription factor ATF-1
, cAMP-dependent transcription factor ATF-1