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evaluation of MAGT1 (show MAGT1 ELISA Kits) and AKAP13 expression in clinical hepatocellular carcinoma tissues by immunohistochemistry suggested that both proteins were strongly expressed in tumor tissues with significantly higher average immunoreactive scores of Remmele and Stegner (IRS (show IARS ELISA Kits)) than in non-tumor tissues
Studied molecular interactions involving anchoring protein AKAP13 in the process of PKA-induced tamoxifen resistance in breast cancer specimens and cell lines.
Isothermal titration calorimetry showed that AKAP-Lbc has only micromolar affinity for RhoA, which combined with the presence of potential binding pockets for small molecules on AKAP-Lbc, raises the possibility of targeting AKAP-Lbc with GEF inhibitors.
pleckstrin (show PLEK ELISA Kits) homology (PH) domain of Lbc is located at the C-terminal end of the protein and is shown here to specifically recognize activated RhoA (show RHOA ELISA Kits) rather than lipids
activation of IKKbeta (show IKBKB ELISA Kits) within the AKAP-Lbc complex promotes NF-kappaB (show NFKB1 ELISA Kits)-dependent production of interleukin-6 (show IL6 ELISA Kits)
Shp2 (show PTPN11 ELISA Kits) is a component of the AKAP-Lbc complex and is inhibited by protein kinase A under pathological hypertrophic conditions in the heart.
Thus AKAP-Lbc may serve an ancillary cardioprotective role by favouring the association of PKA with Hsp20 (show HSPB6 ELISA Kits).
Amplification of AKAP-13 is associated with metastatic and aggressive papillary thyroid carcinomas.
One SNP (rs11638762), in the GATA-3 (show GATA3 ELISA Kits) binding site upstream of the AKAP13 gene, was significantly replicated in another cohort for systolic blood pressure
A-kinase anchoring protein (AKAP)-Lbc anchors a PKN (show PKN1 ELISA Kits)-based signaling complex involved in alpha1-adrenergic receptor-induced p38 (show CRK ELISA Kits) activation.
These findings suggest that Akap13 haploinsufficient mice have a deficiency in early osteogenesis with a corresponding reduction in osteoblast number, but no impairment of mature osteoblast activity.
Our results show that AKAP13-PKD1 (show PKD1 ELISA Kits) signaling is critical for transcriptional regulation of key contractile, cell death, and metabolic pathways during the development of compensatory hypertrophy in vivo.
The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophy.
AKAP13 Rho-GEF (show ARHGEF2 ELISA Kits) and PKD (show PRKD1 ELISA Kits)-binding domains are important for normal cardiac contractility.
AKAP-Lbc assembles a signaling complex composed of the kinases PKN (show PKN1 ELISA Kits), MLTK (show ZAK ELISA Kits), MKK3 (show MAP2K3 ELISA Kits), and p38 alpha (show MAPK14 ELISA Kits) that mediates the activation of p38 (show CRK ELISA Kits) in cardiomyocytes in response to stress signals.
Cardiomyocytes of Akap13-null mice had deficient sarcomere formation, and developing hearts were thin-walled and mice died at embryonic day 10.5-11.0.
AKAP13 plays a role in TLR2-mediated NF-kappaB activation; GEF-containing scaffold proteins may confer specificity to innate immune responses downstream of TLRs
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta.
A kinase (PRKA) anchor protein 13
, A kinase anchor protein 13 isoform-like
, A-kinase anchor protein 13-like
, A-kinase anchor protein 13
, a-kinase anchor protein 13-like
, A-kinase anchoring protein
, LBC oncogene
, breast cancer nuclear receptor-binding auxiliary protein
, guanine nucleotide exchange factor Lbc
, human thyroid-anchoring protein 31
, lymphoid blast crisis oncogene
, non-oncogenic Rho GTPase-specific GTP exchange factor
, protein kinase A-anchoring protein 13
, protein kinase A anchoring protein Rt31
, type II cAMP-dependent protein kinase anchoring protein Ht31