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RhoGEF plays essential role in ciliated epithelia during vertebrate development.
Agonist-induced Ca2 (show CA2 Proteins)+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.
Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF and leukemia-associated RhoGEF (LARG (show ARHGEF12 Proteins)), use their PDZ domains to bind class B plexins and play critical roles in signaling.
Results provide new evidence that ARHGEF11 may constitute a risk factor for schizophrenia
Regulated localization is sufficient for hormonal control of regulator of G protein signaling homology Rho guanine nucleotide exchange factors (RH-RhoGEFs).
analysis of molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF
Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS (show PITX2 Proteins))-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG (show ARHGEF12 Proteins)).
The R1467H polymorphism of ARHGEF11 gene may contribute to susceptibility to type 2 diabetes mellitus and insulin (show INS Proteins) resistance in a Chinese population.
Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho-GEF (show SLC2A4RG Proteins)(LARG (show ARHGEF12 Proteins)) and this protein.
PDZ-RhoGEF interacts directly with p21-activated kinase 4 (show PAK4 Proteins) to negatively regulate the activation of Rho
PDZ-RhoGEF interacts with the actin cytoskeleton
These results demonstrate that PDZ-RhoGEF acts as a key determinant of mammalian metabolism and obesity-associated pathologies.
PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation.
results suggest that ARHGEF11 mediates RhoA (show RHOA Proteins)-myosin light chain signaling pathways at cell-cell junctions, functioning in cooperation with ZO-1 (show TJP1 Proteins)
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.
, rho guanine nucleotide exchange factor 11
, Rho guanine nucleotide exchange factor (GEF) 11
, rho guanine nucleotide exchange factor 11-like
, Rho guanine exchange factor (GEF) 11
, RhoA-specific guanine nucleotide exchange factor
, RhoGEF glutamate transport modulator
, glutamate transporter EAAT4-associated protein 48
, RhoGEF glutamate transport modulator GTRAP48
, glutamate transporter EAAT4 associated protein 48