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anti-Human ARHGEF12 Antibodies:
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that leukemia-associated Rho guanine-nucleotide exchange factor can be directly phosphorylated by cyclin-dependent kinase 1 (show CDK1 Antibodies)
Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF (show ARHGEF11 Antibodies) and leukemia-associated RhoGEF (LARG), use their PDZ (show INADL Antibodies) domains to bind class B plexins and play critical roles in signaling.
this study identified a novel association between IOP and ARHGEF12.
TGF-beta (show TGFB1 Antibodies) regulates LARG and GEF-H1 (show ARHGEF2 Antibodies) during epithelial-mesenchymal transition to affect stiffening response to force and cell invasion.
LARG is a novel and temporally distinct Rho Guanine Nucleotide Exchange Factor (show ARHGEF28 Antibodies) required for completion of abscission.
Data indicate that ICAM-1 (show ICAM1 Antibodies) signaling activates leukemia-associated Rho guanine nucleotide exchange factor (LARG), also known as Rho GEF (show SLC2A4RG Antibodies) 12 (ARHGEF12).
Agonist-induced Ca2 (show CA2 Antibodies)+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.
RhoGEF (show ARHGEF11 Antibodies) activity of p210 (show EVPL Antibodies) BCR/ABL (show ABL1 Antibodies) directly contributes to transforming activity, and may account for the difference in disease outcome associated with p190 (show CNTNAP1 Antibodies) BCR/ABL (show ABL1 Antibodies) and p210 (show EVPL Antibodies) BCR/ABL (show ABL1 Antibodies).
NIS (show SLC5A5 Antibodies) enhanced cell migration and invasion by binding to leukemia-associated RhoA (show RHOA Antibodies) guanine exchange factor
The PDZ domain (show INADL Antibodies) of LARG is required HRH1 (show DHX8 Antibodies)-mediated activation of the strictly Rho-dependent transcriptional activity of serum response factor and can be mimicked by activated Galpha(q (show GNAQ Antibodies))(Q209L).
LARG may play a housekeeper role in regulating constitutive RhoA (show RHOA Antibodies) activity. Its role in regulating platelet function may principally be through RhoA (show RHOA Antibodies)-independent pathways.
The increase in LARG expression was accompanied by a significant increase in ACh (show FGFR3 Antibodies)-stimulated Rho kinase (show ROCK2 Antibodies) and ZIP kinase (show DAPK3 Antibodies) activities, and sustained muscle contraction
PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation.
LARG is activated by the Src family tyrosine kinase Fyn, whereas GEF-H1 catalytic activity is enhanced by ERK downstream of a signalling cascade that includes FAK and Ras
new insight into the mechanism by which p115RhoGEF (show ARHGEF1 Antibodies) is activated by Galpha (show SUCLG1 Antibodies)(13).
S1PR2 (show S1PR2 Antibodies)-dependent activation of RhoA (show RHOA Antibodies) in smooth muscle cells is mediated by LARG and that this signaling mechanism promotes the differentiated SMC (show DYM Antibodies) phenotype.
Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q (show GNAQ Antibodies)-coupled activation of RhoA (show RHOA Antibodies) (larg protein)
We demonstrate colocalization of the LARG protein with the IGF-1 (show IGF1 Antibodies) receptor, suggesting a potential physiologic role for LARG as an activator of RhoA (show RHOA Antibodies) in response to IGF-1 (show IGF1 Antibodies).
mLARG is highly expressed in hematopoietic stem cell fractions, as well as in immature erythroid cells, and provide further support to the hypothesis of the potential involvement of LARG in regulation of early stages of hematopoiesis.
cDNA of LARG (leukemia-associated guanine nucleotide exchange factor) was identified, and its gene expression was observed to be downregulated under clinorotation, which subsequently resulted in the repression of RhoA (show RHOA Antibodies) activation
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.
guanine nucleotide exchange factor
, Rho guanine nucleotide exchange factor (GEF) 12
, rho guanine nucleotide exchange factor 12-like
, leukemia-associated RhoGEF
, leukemia-associated rho guanine nucleotide exchange factor
, rho guanine nucleotide exchange factor 12
, leukemia-associated Rho guanine-nucleotide exchange factor
, leukemia-associated Rho guanine nucleotide exchange factor