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These data demonstrate, that in addition to microtubule-independent Tiam1 (show TIAM1 Proteins) activation, HGF (show HGF Proteins) engages additional microtubule- and APC (show APC Proteins)-dependent pathway of Asef activation.
these results demonstrate potent anti-inflammatory effects by HGF (show HGF Proteins) and delineate a key role of Asef in the mediation of the HGF (show HGF Proteins) barrier protective and anti-inflammatory effects.
Expression of Asef was associated with lower estimated glomerular filtration rate in kidney disease.
Expression of ARHGEF4 (Rho guanine nucleotide exchange factor 4) is restricted to the brain and may regulate the actin cytoskeletal network, cell morphology and migration, and neuronal function
structures thus elucidate the molecular mechanism of Asef recognition by APC (show APC Proteins)
Forced expression of Asef in vitro induced and maintained proliferation of haemaopoietic progenitor cells and co-operated with TEL-AML1 greatly to enhance proliferation and haemopoietic colony size
Positive role of Tyr94 phosphorylation in EGF-induced Asef activation following the activation of Rac1.
Asef and APC (show APC Proteins) function downstream of HGF (show HGF Proteins) and PI3-kinase (show PIK3CA Proteins), and play critical roles in growth factor-mediated regulation of cell morphology and migration
Asef has a role in HGF (show HGF Proteins)-mediated protection against endothelial hyperpermeability and lung injury.
Asef and Asef2 (show SPATA13 Proteins) are required for adenoma formation in Apc (show APC Proteins)(Min/+)mice.
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to rat collybistin protein. Alternative splicing of this gene generates two transcript variants which encode different isoforms. Also there is possibility for the usage of multiple polyadenylation sites for this gene.
Rho guanine nucleotide exchange factor (GEF) 4
, Rho guanine nucleotide exchange factor 4
, rho guanine nucleotide exchange factor 4
, rho guanine nucleotide exchange factor 4-like
, APC-stimulated guanine nucleotide exchange factor 1
, APC-stimulated guanine nucleotide exchange factor