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No mutation in DNAL4 in Congenital mirror movements.
DNAL4 may play a role in the cytoplasmic dynein (show DYNC1H1 ELISA Kits) complex for netrin-1 (show NTN1 ELISA Kits)-directed retrograde transport, and in commissural neurons of the corpus callosum in particular. This could lead to faulty cross-brain wiring, resulting in Mirror movements (MRMV).
DNAL4 is a component of the dynein motor complex (Iwasaki et al., 2005
dynein light chain 4, axonemal
, dynein, axonemal, light polypeptide 4
, dynein, axonemal, light chain 4
, dynein light chain, outer arm 4
, dynein, axonemal, light 4
, proliferation-inducing gene 27
, proliferation-inducing protein 27
, dynein, axon, light chain 4
, outer arm dynein light chain 4