Browse our DUSP6 Proteins (DUSP6)

On are 7 Dual Specificity Phosphatase 6 (DUSP6) Proteins from 5 different suppliers available. Additionally we are shipping DUSP6 Antibodies (126) and DUSP6 Kits (4) and many more products for this protein. A total of 146 DUSP6 products are currently listed.
1300019I03Rik, dusp6, fd19d04, HH19, MKP-3, MKP3, PYST1, wu:fd19d04, wu:fd99d09, zgc:55957, zgc:77211
list all proteins Gene Name GeneID UniProt
DUSP6 1848 Q16828
DUSP6 67603 Q9DBB1
Rat DUSP6 DUSP6 116663 Q64346

DUSP6 Proteins (DUSP6) by Origin

More Proteins for DUSP6 Interaction Partners

Zebrafish Dual Specificity Phosphatase 6 (DUSP6) interaction partners

  1. Lef1 (show LEF1 Proteins) has a role in regulating Dusp6 in formation of the zebrafish posterior lateral line primordium

  2. During fin development, dusp6, a known MAPK/ERK (show MAPK1 Proteins) regulator, is induced in the mesoderm by FGF8 (show FGF8 Proteins) signaling, through the PI3 (show PI3 Proteins)/Akt (show AKT1 Proteins) pathway.

  3. During fin development, dusp6, a known MAPK/ERK (show MAPK1 Proteins) regulator, is induced in the mesoderm by FGF8 (show FGF8 Proteins) signaling, through the PI3 (show PI3 Proteins)/Akt (show AKT1 Proteins) pathway.

  4. Mkp3 encodes a feedback attenuator of the FGF pathway, the expression of which is initiated at an early stage so as to ensure correct FGF signaling levels at the time of axial patterning.

Xenopus laevis Dual Specificity Phosphatase 6 (DUSP6) interaction partners

  1. Retinoic acid-dependent control of MAP kinase phosphatase-3 is necessary for early kidney development.

Human Dual Specificity Phosphatase 6 (DUSP6) interaction partners

  1. PICSAR has a role in promoting cSCC (show CYP11A1 Proteins) progression via activation of extracellular signal-regulated kinase 1/2 (show MAPK3 Proteins) signaling pathway by downregulating DUSP6 expression

  2. DUSP6 rs2279574 SNPs was not associated with chemoradiotherapy response, whereas tumor regression, weight loss, clinical stage, and cigarette smoking were independent prognostic predictors for these Chinese patients with non-small cell lung cancer.

  3. DNA samples from each patient were genotyped for DUSP6 and TOP2A (show TOP2A Proteins) SNPs

  4. Suppression of the FOXA1 (show FOXA1 Proteins)/DUSP6 signaling pathway may contribute to the development of Hirschsprung disease.

  5. These observations led us to conclude that increased TSH signaling overcomes OIS and is essential for B-RafV600E-induced papillary thyroid carcinogenesis.

  6. Dusp6 expression was higher in progestin-sensitive atypical endometrial hyperplasia groups compared with progestin-resistant groups. After treatment, Dusp6 expression was upregulated in progestin-sensitive groups, but not in progestin-resistant groups.

  7. Our results suggest that DUSP6 gene expression in tumour samples may be a prognostic marker in NSCLC

  8. DUSP6 downregulated the expression of matrix metallopeptidase 3 (show MMP3 Proteins).

  9. These results therefore indicate that p53-mediated up-regulation of MKP-3 contributes to the establishment of the senescent cellular phenotype through dephosphorylating ERK1/2

  10. Downregulation of Dusp6, Sprouty4, and Sef--negative modulators of FGF2/ERK1/2 signaling--was present in eutopic endometria of adenomyosis, which may play critical roles in the development of adenomyosis.

Mouse (Murine) Dual Specificity Phosphatase 6 (DUSP6) interaction partners

  1. this study shows that CCL2 (show CCL2 Proteins) supports the classical activation of macrophages, with miR (show MLXIP Proteins)-9 mediated down-regulation of Dusp6 and enhanced ERK (show EPHB2 Proteins)-mediated signal transduction possibly mediating this enhanced pro-inflammatory gene expression

  2. Mitogen-activated protein kinase phosphatase 3 upregulation requires the activation of the Erk1/2 pathway, which correlates with the shutdown of this pathway.

  3. MKP3 could be an important factor in the regulation of brown adipocyte differentiation.

  4. DUSP6 regulates CD4 (show CD4 Proteins)+ T-cell activation and differentiation by inhibiting the TCR-dependent ERK1/2 activation and restraining spontaneous colitis in IL-10 (show IL10 Proteins)-deficient mice.

  5. exercised obese mice had a lower expression of MKP-3 and FoxO1 (show FOXO1 Proteins)/MKP-3 association in the liver

  6. c-Myb (show MYB Proteins) plays an important role in H-Ras (show HRAS Proteins)-induced MKP-3 transcription

  7. Mice lacking MKP-3 protein develop an abnormal persistent state of mechanical allodynia following plantar incision, concurrent with long-lasting spinal phosphorylation of ERK-1 (show MAPK3 Proteins)/2 and p38 (show CRK Proteins).

  8. Depletion of DUSP6 reduced the viability of cancer cell lines and increased the cytotoxicity of EGFR (show EGFR Proteins) and other targeted inhibitors, and cytotoxic agents.

  9. LH/hCG (show CGA Proteins) tightly up-regulates MKP-3 which in turn, dephosphorylates ERK1/2 and drives p21 expression.

  10. dual specificity phosphatases (Dusps) 6 and 14 are up-regulated by activation of beta-catenin (show CTNNB1 Proteins) in murine liver cells

DUSP6 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with DUSP6

  • dual specificity phosphatase 7 (dusp7)
  • dual specificity phosphatase 6 (dusp6)
  • dual specificity phosphatase 6 (DUSP6)
  • dual specificity phosphatase 6 (LOC100222847)
  • Dual specificity protein phosphatase 6 (dus6)
  • dual specificity phosphatase 6 (Dusp6)
  • 1300019I03Rik protein
  • dusp6 protein
  • fd19d04 protein
  • HH19 protein
  • MKP-3 protein
  • MKP3 protein
  • PYST1 protein
  • wu:fd19d04 protein
  • wu:fd99d09 protein
  • zgc:55957 protein
  • zgc:77211 protein

Protein level used designations for DUSP6

dual specificity phosphatase 6 , dual specificity protein phosphatase 7 , dual specificity protein phosphatase 6 , etID14116.25 , MAP kinase phosphatase X17C , Dual specificity protein phosphatase 6 , dual specificity protein phosphatase 6-like , MAP kinase phosphatase 3 , dual specificity protein phosphatase PYST1 , mitogen-activated protein kinase phosphatase 3 , serine/threonine specific protein phosphatase , MKP-3

327246 Danio rerio
353314 Danio rerio
374272 Gallus gallus
398829 Xenopus laevis
452115 Pan troglodytes
733815 Xenopus (Silurana) tropicalis
100137150 Takifugu rubripes
100222847 Taeniopygia guttata
100306828 Salmo salar
100409879 Callithrix jacchus
100466694 Ailuropoda melanoleuca
100051565 Equus caballus
100136684 Oncorhynchus mykiss
100460800 Pongo abelii
100588912 Nomascus leucogenys
1848 Homo sapiens
67603 Mus musculus
116663 Rattus norvegicus
515310 Bos taurus
482594 Canis lupus familiaris
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