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FYVE, RhoGEF and PH Domain Containing 4 ELISA Kits (FGD4)
On are 0 FYVE, RhoGEF and PH Domain Containing 4 (FGD4) ELISA Kits from different suppliers available. Additionally we are shipping FGD4 Antibodies (29) and FGD4 Proteins (4) and many more products for this protein. A total of 35 FGD4 products are currently listed.
9030023J02Rik, 9330209B17Rik, CMT4H, Frabp, ZFYVE6
list all ELISA KIts Gene Name GeneID UniProt
Human FGD4 FGD4 121512 Q96M96
Mouse FGD4 FGD4 224014 Q91ZT5
Rat FGD4 FGD4 246174 O88387

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More ELISA Kits for FGD4 Interaction Partners

Human FYVE, RhoGEF and PH Domain Containing 4 (FGD4) interaction partners

  1. FGD4 c.2044-236 A-allele carriers had an increased risk of paclitaxel dose reduction (HR per A-allele=1.38, P=0.036) when adjusted for total cumulative paclitaxel dose

  2. identified two different pairs of novel compound heterozygous mutations in the FGD4 gene from nonconsanguineous Korean Charcot-Marie-Tooth disease type 4H families

  3. Our results suggest that FGD4 should be screened in other early-onset CMT subtypes, regardless of the severity of the phenotype, and particularly in patients of consanguineous descent.

  4. A single nucleotide polymorphism in FGD4 was associated with the onset of paclitaxel-induced sensory peripheral neuropathy.

  5. LMP1 (show PDLIM7 ELISA Kits), through its transmembrane domains, directly bound FGD4 and enhanced FGD4 activity toward Cdc42 (show CDC42 ELISA Kits), leading to actin cytoskeleton rearrangement and increased motility of NPC (show NPC1 ELISA Kits) cells.

  6. we have identified two novel missense mutations in FGD4 in two patients affected by autosomal recessive demyelinating Charcot-Marie-Tooth disease

  7. role of frabin, a guanine nucleotide exchange factor (show RASGRF1 ELISA Kits) specific for Cdc42 (show CDC42 ELISA Kits), in the activation of Cdc42 (show CDC42 ELISA Kits) during Cryptosporidium parvum infection of biliary epithelial cells

  8. The identification of mutations in FGD4, encoding FGD4 or FRABIN (FGD1-related F-actin binding protein), in families with Charcot-Marie-Tooth type 4H.

  9. We report that disruption of frabin/FGD4, a GEF for the Rho GTPase (show RACGAP1 ELISA Kits) cell-division cycle 42 (Cdc42 (show CDC42 ELISA Kits)), causes peripheral nerve demyelination in patients with autosomal recessive Charcot-Marie-Tooth (CMT) neuropathy.

  10. A novel homozygous Frabin (FGD4) nonsense mutation p.R275X is identified in a family with Charcot-Marie Tooth disease (CMT4H) from Northern Ireland.

Mouse (Murine) FYVE, RhoGEF and PH Domain Containing 4 (FGD4) interaction partners

  1. The enrichment of activated Cdc42 (show CDC42 ELISA Kits) in SSeCKS (show AKAP12 ELISA Kits)-null leading edge filopodia correlated with recruitment of the Cdc42 (show CDC42 ELISA Kits)-specific guanine nucleotide exchange factor (show ARHGEF12 ELISA Kits), Frabin.

  2. This study demonistrated that the disease-initiating event in CMT4H is loss of a Schwann cell-specific cellular function of Frabin/Fgd4.

FGD4 Antigen Profile

Antigen Summary

This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system.

Alternative names and synonyms associated with FGD4

  • FYVE, RhoGEF and PH domain containing 4 (FGD4) Elisa Kit
  • FYVE, RhoGEF and PH domain containing 4 (Fgd4) Elisa Kit
  • 9030023J02Rik Elisa Kit
  • 9330209B17Rik Elisa Kit
  • CMT4H Elisa Kit
  • Frabp Elisa Kit
  • ZFYVE6 Elisa Kit

Protein level used designations for FGD4

FGD1 family, member 4 , FGD1-related F-actin-binding protein , FYVE, RhoGEF and PH domain-containing protein 4 , actin-filament binding protein frabin , zinc finger FYVE domain-containing protein 6 , Fgd1-related F-actin-binding protein , actin filament-binding protein frabin , frabin

121512 Homo sapiens
224014 Mus musculus
246174 Rattus norvegicus
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