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Human Monoclonal HDAC2 Primary Antibody for ICC, IF - ABIN2668730
Nayak, Glöckner-Pagel, Vaeth, Schumann, Buttmann, Bopp, Schmitt, Serfling, Berberich-Siebelt: Sumoylation of the transcription factor NFATc1 leads to its subnuclear relocalization and interleukin-2 repression by histone deacetylase. in The Journal of biological chemistry 2009
Show all 3 Pubmed References
Chicken Polyclonal HDAC2 Primary Antibody for ICC, WB - ABIN223296
Mao, Hou, Cao, Wang, Li, Chen, Fei, Hurren, Gronda, Wu, Trudel, Schimmer: The tricyclic antidepressant amitriptyline inhibits D-cyclin transactivation and induces myeloma cell apoptosis by inhibiting histone deacetylases: in vitro and in silico evidence. in Molecular pharmacology 2011
Show all 3 Pubmed References
Human Monoclonal HDAC2 Primary Antibody for WB - ABIN1882048
Yang, Inouye, Zeng, Bearss, Seto: Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. in Proceedings of the National Academy of Sciences of the United States of America 1996
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Human Polyclonal HDAC2 Primary Antibody for IP - ABIN151654
Huang, Kesselman, Kizub, Guerrero-Preston, Ratovitski: Phospho-?Np63?/microRNA feedback regulation in squamous carcinoma cells upon cisplatin exposure. in Cell cycle (Georgetown, Tex.) 2013
Human Polyclonal HDAC2 Primary Antibody for ICC, IF - ABIN4317578
Sirchia, Faversani, Rovina, Russo, Paganini, Savi, Augello, Rosso, Del Gobbo, Tabano, Bosari, Miozzo: Epigenetic effects of chromatin remodeling agents on organotypic cultures. in Epigenomics 2016
Human Polyclonal HDAC2 Primary Antibody for ELISA, ICC - ABIN4317573
de Ruijter, van Gennip, Caron, Kemp, van Kuilenburg: Histone deacetylases (HDACs): characterization of the classical HDAC family. in The Biochemical journal 2003
Human Polyclonal HDAC2 Primary Antibody for IF (p), IHC (p) - ABIN801348
Jou, Chen, Liu, Way, Lai, Hua, Wang, Huang, Kao, Lin: Quantitative phosphoproteomic analysis reveals ?-bisabolene inducing p53-mediated apoptosis of human oral squamous cell carcinoma via HDAC2 inhibition and ERK1/2 activation. in Proteomics 2015
Mouse (Murine) Monoclonal HDAC2 Primary Antibody for ChIP, ICC - ABIN1042602
Zupkovitz, Tischler, Posch, Sadzak, Ramsauer, Egger, Grausenburger, Schweifer, Chiocca, Decker, Seiser: Negative and positive regulation of gene expression by mouse histone deacetylase 1. in Molecular and cellular biology 2006
Human Polyclonal HDAC2 Primary Antibody for WB - ABIN966259
Betz, Gray, Ekström, Larsson, Ekström: Human histone deacetylase 2, HDAC2 (Human RPD3), is localized to 6q21 by radiation hybrid mapping. in Genomics 1998
Human Polyclonal HDAC2 Primary Antibody for ICC, IF - ABIN4317577
Baek, Park, Rhim, Park, Kim, Kim, Nam: Immunohistochemical Characterization of Histone Deacetylase as a Potential Prognostic Marker and Therapeutic Target in Endometrial Stromal Sarcoma. in Anticancer research 2016
This study demonstrated that the Expression of HDAC2 Transcript Is Reduced in Dorsolateral Prefrontal Cortex of Patients with Schizophrenia.
The findings suggest that miR (show MLXIP Antibodies)-455-3p plays a critical role during chondrogenesis by directly targeting HDAC2/8 and promoting histone H3 (show HIST3H3 Antibodies) acetylation.
report the interaction between CFTR (show CFTR Antibodies) and HDAC2, and its involvement in the development of Ph+ leukemia
Results indicate that HCV core induced epithelial-mesenchymal transition (EMT (show ITK Antibodies)) by interacting with the transcriptional repressor complex Snail (show SNAI1 Antibodies)/HDAC1 (show HDAC1 Antibodies)/2 at the E-cadherin (show CDH1 Antibodies) promoter, which led to E-cadherin (show CDH1 Antibodies) repression and increased invasiveness of hepatoma cells.
Coexpression of SALL4 (show SALL4 Antibodies) with HDAC1 (show HDAC1 Antibodies) and/or HDAC2 was associated with PTEN (show PTEN Antibodies) underexpression and a poor prognosis in hepatocellular carcinoma.
Acetylation-dependent control of global poly(A) RNA degradation by CBP/p300 (show CREBBP Antibodies) and HDAC1-HDAC2 (show HDAC1 Antibodies) has been described.
USP4 (show USP4 Antibodies) inhibits p53 (show TP53 Antibodies) and NF-kappaB (show NFKB1 Antibodies) through deubiquitinating and stabilizing HDAC2
Histone deacetylase (show HDAC1 Antibodies) assays confirmed that MIER2 (show MIER2 Antibodies), but not MIER3 (show MIER3 Antibodies) complexes, have associated deacetylase activity.
HDAC2 controls ciliogenesis independently of Kras, which facilitates Aurora A (show AURKA Antibodies) expression. These studies suggest that HDAC2 is a novel regulator of primary cilium formation in PDAC cells.
class I HDACs (HDAC1 (show HDAC1 Antibodies), 2, 3 and 8) play a major role in regulating extracellular matrix and Epithelial-mesenchymal transition, whereas class IIa HDACs (HDAC4 (show HDAC4 Antibodies) and 5) are less effective.
Treatment of the haplotype Npr1 (show NPR1 Antibodies)(+/-) mice with histone deacetylase (show HDAC1 Antibodies) inhibitors significantly lowered blood pressure and reduced the renal inflammation and fibrosis involving the interactive roles of HDAC1 (show HDAC1 Antibodies)/2, NF-kappaB (show NFKB1 Antibodies) (p65 (show NFkBP65 Antibodies)), and STAT1 (show STAT1 Antibodies).
Our study indicates that ischemia-induced histone deacetylase 2 upregulation from 5 to 7 d after stroke mediates the secondary functional loss by reducing survival and neuroplasticity of peri (show POSTN Antibodies)-infarct neurons as well as augmenting neuroinflammation. Thus, precisely targeting histone deacetylase 2 in the window phase provides a novel therapeutic strategy for stroke recovery.
Taken together, Fam60a is an essential core subunit of a variant Sin3a (show SIN3A Antibodies)-Hdac (show HDAC3 Antibodies) complex in embryonic stem cells that is required to promote rapid proliferation and prevent unscheduled differentiation.
provide new insight into the upstream regulation of Sap90/Psd95 (show DLG4 Antibodies)-associated protein 3 (show HSPB3 Antibodies) and establish the essential role of striatal Hdac1 (show HDAC1 Antibodies), Hdac2 and MeCP2 for suppression of repetitive behaviors
this study shows that infection-induced miR (show MLXIP Antibodies)-21 promotes severe, steroid-insensitive allergic airway disease by suppressing HDAC2
observations suggest that Methamphetamine may induce large-scale transcriptional changes in the Nuc (show SREBF2 Antibodies). Accumbens by regulating the expression of several histone deacetylases in part, via HDAC2-dependent mechanisms.
We also found that glucocorticoid receptor (GR (show NR3C1 Antibodies))-mediated histone deacetylase 2 (HDAC) 2 expression and activity are reduced in the Trpv1 (show TRPV1 Antibodies)(-/-) mice and that HDAC2-regulated, cell-cycle- and neuroplasticity-related molecules are altered
CRISPR/Cas9-mediated disruption of the Hdac2 gene increased Slc2a1 expression, suggesting that it is one of the responsible histone deacetylases (HDACs). These results confirm that b-OHB is a HDAC inhibitor and show that b-OHB plays an important role in fasting-induced epigenetic activation of a glucose transporter gene in the brain.
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.
YY1-associated factor 1
, transcriptional regulator homolog RPD3
, YY1 transcription factor-binding protein
, histone deacetylase-2