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We show that myelin-associated glycoprotein or CNS myelin, in general, inhibit rodent Schwann cell migration and induce their death via cleavage of the neurotrophin (show BDNF ELISA Kits) receptor p75 (show NGFR ELISA Kits).
Results show that MAG is important for axon-glia contact in a model for Charcot-Marie-Tooth disease type 1A, and suggest that its increased expression in patients has a compensatory role in the disease pathology
the apparent dependency on sulfatide for maintaining Nfasc155 and MAG associations is intriguing since the fatty acid composition of sulfatide is altered and paranodal ultrastructure is compromised in multiple sclerosis
LRP1 (show LRP1 ELISA Kits) assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator (show PLAT ELISA Kits) and myelin-associated glycoprotein.
Heteronuclear ribonucleoprotein (show RBP31 ELISA Kits) A1 interacts with an element that overlaps the 5' splice site of Mag exon 12.
Ablation of neuronal ceramide synthase 1 (show CERS1 ELISA Kits) in mice decreases ganglioside levels and expression of myelin-associated glycoprotein in oligodendrocytes.
MAG-mediated axon protection against VNC is suppressed in CRMP4-/- DRG neurons.
myelin-associated glycoprotein (MAG) performs distinct actions on the formation, maturation, degeneration and regeneration of sciatic nerve myelin sheath.
This study suggested that MAG engages membrane-domain resident neuronal receptors to protect neurons from excitotoxicity, and that soluble MAG mitigates excitotoxic damage in vivo.
Quaking I controls a unique cytoplasmic pathway that regulates alternative splicing of myelin-associated glycoprotein.
polyneuropathy associated with anti-MAG antibodies is less homogeneous.
This study identify involvement of myelin-associated glycoprotein in this family with a disorder affecting the central and peripheral nervous system, and suggest that loss of the protein function is responsible for the unique clinical phenotype
Increased serum levels of MAG (and MBP (show MBL2 ELISA Kits)) were found in autistic patients with allergic manifestations compared to those without these manifestations.
Primary mitochondrial respiratory chain defects affecting the white matter, and unrelated to inflammation, are associated with MAG loss and central nervous system demyelination.
Distal acquired demyelinating symmetric neuropathy without anti-MAG antibodies is more likely to be considered a variant of chronic inflammatory demyelinating polyradiculoneuropathy, including a hematological or immunological condition.
polysialylated NCAM (show NCAM1 ELISA Kits) persistence, up-regulated polysialyltransferase-1 (show ST8SIA4 ELISA Kits) mRNA and previously uncovered defective myelin-associated glycoprotein may be early pathogenetic events in adult-onset autosomal-dominant leukodystrophy
Myelin destruction with preferential loss of MAG is found in autopsy brains with acute white matter ischemia as well as in HSV- and CMV-encephalitis.
Possible association of MAG and schizophrenia in a Chinese Han cohort of family trios
The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms have been described for this gene.
, sialic-acid binding protein-4
, myelin associated glycoprotein
, myelin-associated glycoprotein-like
, sialic acid binding Ig-like lectin 4A
, sialic acid-binding immunoglobulin-like lectin 4A
, malignancy-associated protein
, S-MAG (C-term.)
, brain neuron cytoplasmic protein 3
, sialic acid-binding Ig-like lectin 4a