Browse our Melanoma Antigen Family D, 1 Proteins (MAGED1)

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Melanoma Antigen Family D, 1 Proteins (MAGED1)
On are 7 Melanoma Antigen Family D, 1 (MAGED1) Proteins from 3 different suppliers available. Additionally we are shipping Melanoma Antigen Family D, 1 Antibodies (92) and Melanoma Antigen Family D, 1 Kits (1) and many more products for this protein. A total of 107 Melanoma Antigen Family D, 1 products are currently listed.
2810433C11Rik, 5430405L04Rik, Dlixin, Dlxin-1, Dlxin1, DXBwg1492e, MAGE-D1, MAGED1, mFLJ00163, Nrage
list all proteins Gene Name GeneID UniProt
MAGED1 9500 Q9Y5V3
MAGED1 94275 Q9QYH6
MAGED1 84469 Q9ES73

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Melanoma Antigen Family D, 1 Proteins (MAGED1) by Origin

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More Proteins for Melanoma Antigen Family D, 1 Interaction Partners

Human Melanoma Antigen Family D, 1 (MAGED1) interaction partners

  1. these results demonstrate the effective anti-autophagic of NRAGE in non-small-cell lung cancer cells through AMPK (show PRKAA1 Proteins)/Ulk1 (show ULK1 Proteins)/Atg13 (show ATG13 Proteins) autophagy signaling pathways. Therefore, NRAGE could be used as a potential therapeutic target for lung cancer.

  2. MAGED1 binds and positively regulates the transcriptional activity of family members SIM1 (show SIM1 Proteins), SIM2 (show SIM2 Proteins), NPAS4 (show NPAS4 Proteins) and ARNT2 (show ARNT2 Proteins), but does not interact with AhR (show AHR Proteins), HIF1alpha (show HIF1A Proteins) and ARNT (show ARNT Proteins). This interaction is mediated by PAS (show PASK Proteins) repeat regions which also form the interface for bHLH PAS (show PASK Proteins) dimerisation, and accordingly MAGED1 is not found in complex with bHLH PAS (show PASK Proteins) dimers.

  3. our surprise, NRAGE induces nuclear localization of beta-catenin (show CTNNB1 Proteins) and increases its DNA binding ability. Further studies reveal that NRAGE leads to the modification of beta-catenin/Arm with O-linked beta-N-acetylglucosamine (O-GlcNAc (show OGT Proteins)), and failure of the association between beta-catenin/Arm and pygopus(pygo) protein, which is required for transcriptional activation of Wnt (show WNT2 Proteins) target genes. Therefore, our findings suggest a ...

  4. Loss of GSPT2 (show GSPT2 Proteins) and/or MAGED1 function may contribute to the intellectual disability.

  5. The ectopic subcellular localization of NRAGE mediated nuclear translocation of beta-catenin (show CTNNB1 Proteins).

  6. High NRAGE expression is associated with esophageal carcinomas.

  7. MAGE-D1 plays important roles in the central nervous system in both developmental and adult stages.

  8. Univariate and multivariate analyses indicated that MAGED1 expression was an independent prognostic factor in colorectal carcinoma

  9. NRAGE may participate in the formation of radioresistance of TE13R120 cells by changing its subcellular localization, but its relationship with cell apoptosis has not been confirmed.

  10. we establish the roles for Dlxin-1, one as an anti-tumorigenic and anti-invasive protein in high-grade gliomas and the other as an inducer of differentiation of glioma stem cells.

Mouse (Murine) Melanoma Antigen Family D, 1 (MAGED1) interaction partners

  1. MAGED1 as a novel regulator of osteoblastogenesis, osteoclastogenesis, and bone remodeling in a mouse model

  2. Maged1 deficiency prevented the interaction of Maged1 with cAMP response element-binding protein (CREB).

  3. NRAGE is a potent regulator of proliferation and odontoblastic differentiation of mouse dental pulp cells, which might be via the NF-kappaB (show NFKB1 Proteins) signalling pathway.

  4. Show Ror2 (show ROR2 Proteins) expression is higher in highly metastatic cell line than in low metastatic variant cell line. Our data show that Ror2 (show ROR2 Proteins) is a potential factor in the tumorigenesis and metastasis in a Src (show SRC Proteins)-dependent manner that is negatively regulated by NRAGE.

  5. We conclude that Maged1 is required for OT processing or stability. A decrease in mature OT levels in Maged1 mutants affects social interactions and possibly other behavioral processes

  6. Maged1 is involved in osteoblast proliferation and differentiation. Mice deficient in Maged1 protein had decreased bone mineral density (BMD (show BEST1 Proteins))

  7. the present findings suggest a novel role for MAGE-D1 in depressive behaviors: modulating SERT (show SLC6A4 Proteins) ubiquitylation.

  8. XIAP (show XIAP Proteins)-TAB1 (show TAB1 Proteins)-TAK1 (show NR2C2 Proteins) complex is dependent on NRAGE for IKK-alpha (show CHUK Proteins)/beta phosphorylation and NF-kappaB (show NFKB1 Proteins) activation.

  9. MAGED1 binds to nuclear receptor RORalpha to bring about positive and negative effects on core clock genes of Bmal1 (show ARNTL Proteins), Rev-erbalpha (show NR1D1 Proteins) and E4bp4 (show NFIL3 Proteins) expression through the Rev-Erbalpha (show NR1D1 Proteins)/ROR responsive elements (RORE).

  10. NRAGE induces NF-kappaB activation and MIF expression in P19 cells

Melanoma Antigen Family D, 1 (MAGED1) Protein Profile

Protein Summary

This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene.

Alternative names and synonyms associated with Melanoma Antigen Family D, 1 (MAGED1)

  • melanoma antigen family D, 1 (MAGED1)
  • melanoma antigen family D, 1 (LOC100355903)
  • melanoma antigen, family D, 1 (Maged1)
  • 2810433C11Rik protein
  • 5430405L04Rik protein
  • Dlixin protein
  • Dlxin-1 protein
  • Dlxin1 protein
  • DXBwg1492e protein
  • MAGE-D1 protein
  • MAGED1 protein
  • mFLJ00163 protein
  • Nrage protein

Protein level used designations for MAGED1

melanoma antigen family D, 1 , melanoma-associated antigen D1 , melanoma-associated antigen D1-like , MAGE tumor antigen CCF , MAGE-D1 antigen , neurotrophin receptor-interacting MAGE homolog , SNERG-1 , sertoli cell necdin-related gene protein 1

465641 Pan troglodytes
480923 Canis lupus familiaris
512562 Bos taurus
100355903 Oryctolagus cuniculus
100446209 Pongo abelii
100479784 Ailuropoda melanoleuca
100585204 Nomascus leucogenys
9500 Homo sapiens
414852 Sus scrofa
94275 Mus musculus
84469 Rattus norvegicus
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