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we discovered one novel locus (LRP2 (show LRP2 Antibodies); most significant single nucleotide polymorphism rs12988804) that reached genome-wide significance in predicting relapse risk (HR=2.18, p=3.30x10(-8)).
miR (show MLXIP Antibodies)-148b directly down-regulates renal megalin (show LRP2 Antibodies) expression.
Exocytosis-mediated urinary C-megalin (show LRP2 Antibodies) excretion is associated with the development and progression of diabetic nephropathy in T2DM, particularly due to megalin (show LRP2 Antibodies)-mediated lysosomal dysfunction in proximal tubules.
The studies suggest that impaired endocytosis of megalin (show LRP2 Antibodies)/cubilin (show CUBN Antibodies) ligands, hemoglobin (show HBB Antibodies) and albumin (show ALB Antibodies), rather than heme toxicity, may be the cause of tubular proteinuria in sickle cell disease patients.
VDR (show CYP27B1 Antibodies) and MEGALIN (show LRP2 Antibodies) gene variations can alter age-related cognitive trajectories differentially between men and women among African American urban adults, specifically in global mental status and domains of verbal fluency, visual/working memory, and executive function.
the main role for placental megalin (show LRP2 Antibodies) is not to mediate uptake of nutrients from the maternal bloodstream; results point toward novel and complex functions for megalin (show LRP2 Antibodies) in the cytotrophoblasts.
specific miRNA-146a regulation may contribute to Alzheimer's disease by downregulating the Lrp2 (show LRP2 Antibodies)/Akt (show AKT1 Antibodies) pathway
abundances of megalin (show LRP2 Antibodies) and Dab2 (show DAB2 Antibodies) (p = 0.046) were reduced in infected placentas from women with LBW deliveries
homozygous Asp3779Asn and a hemizygous Ile262Met mutations in the LRP2 (show LRP2 Antibodies) and TSPYL2 (show TSPYL2 Antibodies) genes, respectively, in a Pakistani family with two boys affected with mild nonsyndromic intellectual disability
A rare variant in MCF2L has been identified using exclusion linkage in a pedigree with premature atherosclerosis.
the PH domain of Dbs has a role in regulating Rho GTPase (show RACGAP1 Antibodies) activation
the PH domain of Dbs has two roles in the regulation of DH domain function, one for GTPase (show RACGAP1 Antibodies) association and activation in vitro and one for phosphoinositide binding and GTPase (show RACGAP1 Antibodies) interaction in vivo, that together promote Dbs association with membranes.
Dbs is activated by Rac1 at the pleckstrin (show PLEK Antibodies) homology domain
Dbs has the potential to promote proliferation of immature thymocytes, but also sensitizes immature thymocytes to deletion.
Crystal structure of the DH/PH fragment of Dbs without bound GTPase (show RACGAP1 Antibodies)
the Sec14 domain regulates Dbs transformation through at least two distinct mechanisms, neither of which appears to directly influence the in vivo exchange activity of the protein
Dbs transformation is associated with increased phosphorylation of myosin light chain and stress fiber formation, both of which occur in a ROCK-dependent manner
oncogene that can activate small GTP-binding proteins
DBL's big sister
, MCF2 transforming sequence-like protein
, guanine nucleotide exchange factor DBS
, MCF2-transforming sequence-like protein
, OST oncogene
, mcf.2 transforming sequence-like
, MCF.2 cell line derived transforming sequence-like
, coagulation factor VII
, guanine nucleotide exchange factor DBS-like
, Ost gamma
, exchange factor for RhoA and Cdc42
, guanine nucleotide exchange factor OSTIII