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Browse our MCF.2 Cell Line Derived Transforming Sequence-Like Proteins (MCF2L)

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MCF.2 Cell Line Derived Transforming Sequence-Like Proteins (MCF2L)
On www.antibodies-online.com are 4 MCF.2 Cell Line Derived Transforming Sequence-Like (MCF2L) Proteins from 3 different suppliers available. Additionally we are shipping MCF.2 Cell Line Derived Transforming Sequence-Like Antibodies (51) and MCF.2 Cell Line Derived Transforming Sequence-Like Kits (3) and many more products for this protein. A total of 61 MCF.2 Cell Line Derived Transforming Sequence-Like products are currently listed.
Synonyms:
ARHGEF14, C130040G20Rik, Dbs, GP330, mcf 2l, MCF2L, mKIAA0362, NV11503, Ost
list all proteins Gene Name GeneID UniProt
Rat MCF2L MCF2L 100361711  
MCF2L 4036 P98164
MCF2L 17207  

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MCF.2 Cell Line Derived Transforming Sequence-Like Proteins (MCF2L) by Origin

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More Proteins for MCF.2 Cell Line Derived Transforming Sequence-Like Interaction Partners

Human MCF.2 Cell Line Derived Transforming Sequence-Like (MCF2L) interaction partners

  1. homozygous Asp3779Asn and a hemizygous Ile262Met mutations in the LRP2 (show LRP2 Proteins) and TSPYL2 (show TSPYL2 Proteins) genes, respectively, in a Pakistani family with two boys affected with mild nonsyndromic intellectual disability

  2. A rare variant in MCF2L has been identified using exclusion linkage in a pedigree with premature atherosclerosis.

  3. The megalin (show LRP2 Proteins) expression appears to vary inversely with gestational age with the greatest expression noted in the most premature samples. Age-dependent differences in placental megalin (show LRP2 Proteins) may therefore influence fetal exposure.

  4. we are the first to identify the association between LRP2 (show LRP2 Proteins) and gout in a Chinese population and to confirm this association in Asians.

  5. MCF2L is subject to a cis (show CISH Proteins)-acting eQTL (show EQTN Proteins) in synovial membrane that correlates with the OA association signal. This signal contains several functional SNPs that could account for the susceptibility and which therefore merit further investigation

  6. Two novel LRP2 (show LRP2 Proteins) mutations, a homozygous nonsense mutation and a missense mutation in two unrealted families with Donnai-Barrow syndrome.

  7. Loss of LRP2 (show LRP2 Proteins) is associated with buphthalmos

  8. melanoma cell expression of LRP2/megalin (show LRP2 Proteins) significantly decreases melanoma cell proliferation and survival rates.

  9. levels of urinary C-megalin (show LRP2 Proteins) are associated with histological abnormalities in adult IgAN patients

  10. A new mutation in LRP2 (show LRP2 Proteins) causes a predominantly ocular phenotype suggestive of Stickler syndrome.

Mouse (Murine) MCF.2 Cell Line Derived Transforming Sequence-Like (MCF2L) interaction partners

  1. the PH domain of Dbs has a role in regulating Rho GTPase (show RACGAP1 Proteins) activation

  2. the PH domain of Dbs has two roles in the regulation of DH domain function, one for GTPase (show RACGAP1 Proteins) association and activation in vitro and one for phosphoinositide binding and GTPase (show RACGAP1 Proteins) interaction in vivo, that together promote Dbs association with membranes.

  3. Dbs is activated by Rac1 at the pleckstrin (show PLEK Proteins) homology domain

  4. Dbs has the potential to promote proliferation of immature thymocytes, but also sensitizes immature thymocytes to deletion.

  5. Crystal structure of the DH/PH fragment of Dbs without bound GTPase (show RACGAP1 Proteins)

  6. the Sec14 domain regulates Dbs transformation through at least two distinct mechanisms, neither of which appears to directly influence the in vivo exchange activity of the protein

  7. Dbs transformation is associated with increased phosphorylation of myosin light chain and stress fiber formation, both of which occur in a ROCK-dependent manner

MCF.2 Cell Line Derived Transforming Sequence-Like (MCF2L) Protein Profile

Protein Summary

The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling\; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).

Alternative names and synonyms associated with MCF.2 Cell Line Derived Transforming Sequence-Like (MCF2L)

  • MCF.2 cell line derived transforming sequence-like (MCF2L)
  • MCF.2 cell line derived transforming sequence-like (LOC100361711)
  • MCF.2 cell line derived transforming sequence-like (mcf2l.2)
  • MCF.2 cell line derived transforming sequence-like (mcf2l)
  • low density lipoprotein receptor-related protein 2 (LRP2)
  • MCF.2 cell line derived transforming sequence-like (Mcf2l)
  • mcf.2 transforming sequence-like (Mcf2l)
  • ARHGEF14 protein
  • C130040G20Rik protein
  • Dbs protein
  • GP330 protein
  • mcf 2l protein
  • MCF2L protein
  • mKIAA0362 protein
  • NV11503 protein
  • Ost protein

Protein level used designations for MCF2L

guanine nucleotide exchange factor DBS , MCF.2 cell line derived transforming sequence-like , coagulation factor VII , guanine nucleotide exchange factor DBS-like , Heymann nephritis antigen homolog , LRP-2 , calcium sensor protein , glycoprotein 330 , low-density lipoprotein receptor-related protein 2 , megalin , DBL's big sister , MCF2 transforming sequence-like protein , MCF2-transforming sequence-like protein , OST oncogene , mcf.2 transforming sequence-like , Ost gamma , exchange factor for RhoA and Cdc42 , guanine nucleotide exchange factor OSTIII

GENE ID SPECIES
418748 Gallus gallus
452678 Pan troglodytes
485555 Canis lupus familiaris
505595 Bos taurus
100122691 Nasonia vitripennis
100361711 Rattus norvegicus
100380200 Xenopus (Silurana) tropicalis
100549760 Meleagris gallopavo
100559055 Anolis carolinensis
100606412 Nomascus leucogenys
4036 Homo sapiens
23263 Homo sapiens
117020 Rattus norvegicus
17207 Mus musculus
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