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Net1 promotes the angiogenesis in cervical squamous cell carcinomas and siRNA targeting of Net1 can effectively reduce angiogenesis and inhibit tumor growth via VEGF signaling.
AMPK (show PRKAA1 Proteins) phosphorylation of the RHOA (show RHOA Proteins) guanine nucleotide exchange factor (show RASGRF1 Proteins) NET1A inhibits extracellular matrix degradation, an early step in cell invasion
Net1 (show SLC6A2 Proteins) mRNA and protein levels in non-small cell lung cancer tissues were significantly elevated compared with those in their corresponding nontumor tissues.
Simultaneous silencing of NET-1 (show SLC6A2 Proteins) and survivin (show BIRC5 Proteins) using one-chain-double-target siRNA thus provides an advantageous alternative in the development of therapeutics for skin squamous cell carcinoma .
These data indicate that Net1A acetylation regulates its subcellular localization to impact on RhoA activity and actin cytoskeletal organization.
NET1 (show SLC6A2 Proteins) was associated with comorbidity of oppositional defiant disorder and symptoms in Attention-deficit/hyperactivity disorder probands
Net1A plays a plays a previously unrecognized, Rho GTPase (show RACGAP1 Proteins)-independent role in controlling ATM (show ATM Proteins) activity and downstream signaling after DNA damage to impact cell survival.
The overexpression of NET-1 (show SLC6A2 Proteins) in tumor cells may be closely related to the malignant phenotype of skin squamous cell carcinoma including proliferation, invasion and tumor growth.
NET1 (show SLC6A2 Proteins) expression is elevated in OAC and its pre-malignant phenotype, Barrett's oesophagus. NET1 (show SLC6A2 Proteins) promotes OAC cell invasion and proliferation.
NET-1 and VEGF silencing play a key role in inhibiting hepatocellular cell proliferation, promoting apoptosis, and reducing angiogenesis.
Data identify for the first time a role for NET1 in vivo and indicate that NET1 expression is essential for the proliferation and differentiation of mammary epithelial cells in the developing mammary gland.
NET1 has roles in stimulating cytoskeletal reorganization and in transforming cells
PAK1 (show PAK1 Proteins) negatively regulates the activity of NET1
Net1-regulated beta-catenin (show CTNNB1 Proteins) activation plays a crucial role in the dorsal axis formation during zebrafish development.
This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
neuroepithelial cell transforming gene 1
, neuroepithelial cell-transforming gene 1 protein
, neuroepithelial cell transforming 1
, Rho guanine nucleotide exchange factor (GEF) 8
, guanine nucleotide regulatory protein (oncogene)
, neuroepithelioma transforming gene 1
, p65 Net1 proto-oncogene protein
, small GTP-binding protein regulator
, Net1 homolog
, rho guanine nucleotide exchange factor 8