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anti-Mouse (Murine) PCSK5 Antibodies:
anti-Rat (Rattus) PCSK5 Antibodies:
anti-Human PCSK5 Antibodies:
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Human Polyclonal PCSK5 Primary Antibody for WB - ABIN1881639
Heng, Paule, Hardman, Li, Singh, Rainczuk, Stephens, Nie: Posttranslational activation of bone morphogenetic protein 2 is mediated by proprotein convertase 6 during decidualization for pregnancy establishment. in Endocrinology 2010
Show all 3 Pubmed References
Human Polyclonal PCSK5 Primary Antibody for ELISA - ABIN4237337
Jin, Wang, Millar, Quertermous, Rothblat, Glick, Rader: Hepatic proprotein convertases modulate HDL metabolism. in Cell metabolism 2007
Cow (Bovine) Polyclonal PCSK5 Primary Antibody for WB - ABIN2781306
Szumska, Pieles, Essalmani, Bilski, Mesnard, Kaur, Franklyn, El Omari, Jefferis, Bentham, Taylor, Schneider, Arnold, Johnson, Tymowska-Lalanne, Stammers, Clarke, Neubauer, Morris, Brown, Shaw-Smith, Cama, Capra, Ragoussis, Constam, Seidah, Prat, Bhattacha: VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5. in Genes & development 2008
Human Polyclonal PCSK5 Primary Antibody for ICC, IF - ABIN4344009
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
loss of the convertase furin (show FURIN Antibodies) or PC5/6 in hepatocytes results in a approximately 30% decrease in APC (show APC Antibodies) levels, with no significant contribution from PACE4 (show PCSK6 Antibodies). We conclude that prior convertase cleavage of protein C (show PROC Antibodies) in hepatocytes is critical for its thrombin (show F2 Antibodies) activation.
overexpression of PCs, furin (show FURIN Antibodies) and PC5, but not PC7 (show PCSK7 Antibodies), which are all expressed in SMC (show DYM Antibodies), increase PKGI (show PRKG1 Antibodies) cleavage in a dose-dependent manner
Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy.
PCSK5 and GDF11 (show GDF11 Antibodies) expression during hindgut morphogenesis could be key factors for normal anorectal development, which can be disturbed by the administration of an overdose of all-trans retinoic acid, leading to anorectal malformations.
Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.
These data support the role of proconvertase PCSK5 in the processing of ovarian inhibin subunits during folliculogenesis.
Data suggest that intestinal PC5/6 is protective towards tumorigenesis, especially in mouse duodenum, and possibly in human colon.
The proprotein convertase PC5A and a metalloprotease (show ADAMTS7 Antibodies) are involved in the proteolytic processing of the neural adhesion molecule (show CNTN6 Antibodies) L1.
large cysteine-rich region acts as an important part of functional domain of PC6
PC6 is an essential molecule in modulating uterine function to support the establishment of embryo implantation
Case Report: whole exome sequencing of a case with the VACTERL association uncovered a novel frameshift mutation in the PCSK5 gene.
full-length alpha-DG in the human endometrial epithelium is a barrier for embryo attachment and that removal of alpha-DG-N by proprotein convertase 5/6 (PC6; a protease critical for implantation
Proprotein convertase 5/6 cleaves PDGFA (show PDGFA Antibodies) in the human endometrium in preparation for embryo implantation.
PC5/6A is involved in squamous differentiation of human nasal epithelial cells, possibly through up-regulation of the BMP-2 (show BMP2 Antibodies) signaling pathway.
study implicates PC6 as a key regulatory protein essential for the attachment of the blastocyst to the endometrial epithelium through the processing of pro-integrin-alphas
PC6 plays a key role in regulating fundamental cellular remodeling processes, such as plasma membrane transformation and membrane-cytoskeletal interface reorganization.
PC6 may have a role in uterine receptivity and its uterine lavage levels appear to be significantly lower in a subgroup of women with unexplained infertility
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein mediates posttranslational endoproteolytic processing for several integrin alpha subunits. It is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Multiple transcript variants encoding different isoforms have been found for this gene.
proprotein convertase subtilisin/kexin type 5
, proprotein convertase PC6
, proprotein convertase 6A
, proprotein convertase 6B
, proprotein convertase 6C
, proprotein convertase 6D
, proprotein convertase 6E
, proprotein convertase 6F
, subtilisin-like protease SPC6A
, proprotein convertase 5
, proprotein convertase 6
, proprotein convertase PC5
, subtilisin-like proprotein convertase 6
, subtilisin/kexin-like protease PC5
, prohormone convertase 5
, protease PC6