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loss of the convertase furin (show FURIN ELISA Kits) or PC5/6 in hepatocytes results in a approximately 30% decrease in APC (show APC ELISA Kits) levels, with no significant contribution from PACE4 (show PCSK6 ELISA Kits). We conclude that prior convertase cleavage of protein C (show PROC ELISA Kits) in hepatocytes is critical for its thrombin (show F2 ELISA Kits) activation.
overexpression of PCs, furin (show FURIN ELISA Kits) and PC5, but not PC7 (show PCSK7 ELISA Kits), which are all expressed in SMC (show DYM ELISA Kits), increase PKGI (show PRKG1 ELISA Kits) cleavage in a dose-dependent manner
Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy.
PCSK5 and GDF11 (show GDF11 ELISA Kits) expression during hindgut morphogenesis could be key factors for normal anorectal development, which can be disturbed by the administration of an overdose of all-trans retinoic acid, leading to anorectal malformations.
Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.
These data support the role of proconvertase PCSK5 in the processing of ovarian inhibin subunits during folliculogenesis.
Data suggest that intestinal PC5/6 is protective towards tumorigenesis, especially in mouse duodenum, and possibly in human colon.
The proprotein convertase PC5A and a metalloprotease (show ADAMTS7 ELISA Kits) are involved in the proteolytic processing of the neural adhesion molecule (show CNTN6 ELISA Kits) L1.
large cysteine-rich region acts as an important part of functional domain of PC6
PC6 is an essential molecule in modulating uterine function to support the establishment of embryo implantation
Case Report: whole exome sequencing of a case with the VACTERL association uncovered a novel frameshift mutation in the PCSK5 gene.
full-length alpha-DG in the human endometrial epithelium is a barrier for embryo attachment and that removal of alpha-DG-N by proprotein convertase 5/6 (PC6; a protease critical for implantation
Proprotein convertase 5/6 cleaves PDGFA (show PDGFA ELISA Kits) in the human endometrium in preparation for embryo implantation.
PC5/6A is involved in squamous differentiation of human nasal epithelial cells, possibly through up-regulation of the BMP-2 (show BMP2 ELISA Kits) signaling pathway.
study implicates PC6 as a key regulatory protein essential for the attachment of the blastocyst to the endometrial epithelium through the processing of pro-integrin-alphas
PC6 plays a key role in regulating fundamental cellular remodeling processes, such as plasma membrane transformation and membrane-cytoskeletal interface reorganization.
PC6 may have a role in uterine receptivity and its uterine lavage levels appear to be significantly lower in a subgroup of women with unexplained infertility
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein mediates posttranslational endoproteolytic processing for several integrin alpha subunits. It is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Multiple transcript variants encoding different isoforms have been found for this gene.
proprotein convertase subtilisin/kexin type 5
, proprotein convertase PC6
, proprotein convertase 6A
, proprotein convertase 6B
, proprotein convertase 6C
, proprotein convertase 6D
, proprotein convertase 6E
, proprotein convertase 6F
, subtilisin-like protease SPC6A
, proprotein convertase 5
, proprotein convertase 6
, proprotein convertase PC5
, subtilisin-like proprotein convertase 6
, subtilisin/kexin-like protease PC5
, prohormone convertase 5
, protease PC6