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These results implicate PCSK6 in mediation of brain developmental pathways that jointly impact upon handedness, autism and aspects of schizotypy
In summary, our study implicated a gene network involving Tbx5 (show TBX5 ELISA Kits), Osr1 (show OXSR1 ELISA Kits) and Pcsk6 interaction in second heart field for atrial septation, providing a molecular framework for understanding the role of Tbx5 (show TBX5 ELISA Kits) in congenital heart disease ontogeny.
PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways
PACE4-knockdown associated growth deficiencies were established on the knockdown HepG2, Huh7, and HT1080 (show CDC123 ELISA Kits) cells as well as the antiproliferative effects of the multi-Leu peptide supporting the growth capabilities of PACE4 in cancer cells.
identified a PCSK6 mutation that impaired corin (show CORIN ELISA Kits) activation activity in a hypertensive patient
PCSK6 is upregulated in the synovial tissues of patients with rheumatoid arthritis and has a genetic effect on the risk of rheumatoid arthritis. Inhibition of PCSK6 may play a protective role in the development of rheumatoid arthritis.
PCSK6 regulated by LH inhibits the apoptosis of human granulosa cells via activin A (show INHBA ELISA Kits) and TGFbeta2.
miR (show MLXIP ELISA Kits)-124 exhibits antiproliferative and antiaggressive effects on prostate cancer cells through PACE4 pathway.
PCSK6 was detected at increased levels in the fibrous cap of symptomatic carotid plaques, possibly associated with key processes in plaque rupture such as inflammation and extracellular matrix remodeling.
PACE4 has a distinct role in maintaining proliferation and tumor progression in prostate cancer.
PC7 (show PCSK7 ELISA Kits) and the related proteases Furin (show FURIN ELISA Kits) and Pace4 regulate E-cadherin (show CDH1 ELISA Kits) function during blastocyst formation.
Mice overexpressing PACE4 exhibited tumors of increased growth rate.
PACE4 participates in bone formation at least in osteoblast differentiation, and estrogen receptor (show ESR1 ELISA Kits)-mediated stimuli induce osteoblast differentiation through the upregulation of PACE4 expression
we observed an increased susceptibility to UV in single furin (show FURIN ELISA Kits) transgenic mice that was not substantially enhanced in the double furin (show FURIN ELISA Kits)/PACE4 transgenic mice.
A variant in PCSK6 is strongly associated with protection against pain in knee osteoarthritis.
Furin (show FURIN ELISA Kits) and Pace4 are released by the extraembryonic microenvironment, and that they cleave a membrane-bound reporter substrate in adjacent epiblast cells and activate Nodal to maintain pluripotency
PCSK6 activity plays a role in maintaining normal cellular and tissue homeostasis in the ovary.
PACE4, together with other proprotein convertases, are suitable targets to slow down or block tumor progression.
Malignant conversion of non-tumorigenic murine skin keratinocytes overexpressing PACE4
Spc4 regulates Nodal signalling during gastrulation
maternal XPACE4 plays an important role in embryonic patterning by regulating the production of a subset of active mature Transforming Growth Factor beta proteins in specific sites
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression. Alternatively spliced transcript variants encoding different isoforms have been identified.
proprotein convertase PACE4
, proprotein convertase subtilisin/kexin type 6
, proprotein convertase subtilisin/kexin type 6-like
, paired basic amino acid cleaving enzyme 4
, paired basic amino acid cleaving system 4
, subtilisin-like proprotein convertase 4
, subtilisin/kexin-like protease PACE4
, Subtilisin - like endoprotease
, kexin-like protease PC7A
, subtilisin-like kinase SPC4