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Human RALB Primary Antibody for SDS - ABIN667855
Jullien-Flores, Dorseuil, Romero, Letourneur, Saragosti, Berger, Tavitian, Gacon, Camonis: Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. in The Journal of biological chemistry 1995
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These findings suggest that RalB might be one of the targets for facilitating the invasive phenotype of malignant gliomas induced by GGTase-I.
striking isoform-specific consequences of distinct CAAX-signaled posttranslational modifications that contribute to the divergent subcellular localization and activity of RalA (show rala Proteins) and RalB.
expression of K-Ras (show HRAS Proteins) and RalB and possibly RalA (show rala Proteins) proteins is critical for maintaining low levels of p53 (show TP53 Proteins), and down-regulation of these GTPases reactivates p53 (show TP53 Proteins) by significantly enhancing its stability, contributing to suppression of malignant transformation
High RALB mRNA expression is associated with non-small-cell lung cancer growth and progression.
Integrin alpha(v (show ITGAV Proteins))beta expression and the resulting KRAS-RalB-NF-kappaB (show NFKB1 Proteins) pathway were both necessary and sufficient for tumour initiation, anchorage independence, self-renewal and erlotinib resistance.
nutrient starvation induces RALB deubiquitylation by accumulation and relocalization of the deubiquitylase USP33 (show USP33 Proteins) to RALB-positive vesicles
RalA (show rala Proteins) and RalB exhibit both distinct and redundant roles in tumorigenesis (Review).
The study found upregulated RalA (show rala Proteins) and RalB activation in colorectal cancer tumor cell lines and tumors.
the existence of an ubiquitination/de-ubiquitination cycle superimposed on the GDP/GTP (show AK3 Proteins) cycle of RalA (show rala Proteins), involved in the regulation of RalA (show rala Proteins) activity as well as in membrane raft trafficking.
RalA (show rala Proteins) and RalB differentially regulate development of epithelial tight junctions.
findings show either RALA (show rala Proteins) or RALB is sufficient for tumor growth; either RALA (show rala Proteins) or RALB is sufficient for cell proliferation; RALA (show rala Proteins) and RALB act in a redundant fashion
Endogenous RalB plays a negative role in the ingestion process of Fc gamma receptor (show FCGR1A Proteins)-mediated macrophage phagocytosis.
This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors.
RAS-like protein B
, ras related GTP binding protein
, ras-related protein Ral-B
, v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)
, GTP binding protein)
, v-ral simian leukemia viral oncogene homolog B (ras related)