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cells deficient in acid ceramidase (aCDase (show ASAH1 Proteins)) also exhibited defects in CCL5 (show CCL5 Proteins) induction, whereas cells deficient in sphingosine kinase-1 (show SPHK1 Proteins) and -2 exhibited higher levels of CCL5 (show CCL5 Proteins).
nSMase2 has a role in ceramide generation, aberrant apoptosis, and lung injury under cigarette smoke exposure
Neutral sphingomyelinase 1 deficiency in the mouse causes no lipid storage disease. (nSMase 1)
NSMase-2 could be involved in IL-1beta (show IL1B Proteins)-induced JNK (show MAPK8 Proteins) activation in hepatocytes
Nuclear sphingomyelin-synthase and protein kinase C delta (show PKCd Proteins) are expressed in melanoma cells
Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase (show ASAH1 Proteins) have roles in cutaneous aging
Peptidoglycan activates the nSMase/ceramide pathway to induce MKK3 (show MAP2K3 Proteins)/6/p38 MAPK (show MAPK14 Proteins) activation, which in turn initiates NF-kappaB (show NFKB1 Proteins) activation and ultimately induces COX-2 expression in macrophages.
Interestingly, neutral but not acid sphingomyelinase (show SMPD1 Proteins) was mandatory for PorBIA -mediated Neisseria gonorrhoeae invasion into host cells.
nSMase1 (sphingomyelin phosphodiesterase 2, SMPD2)has a common central role in ceramide signaling during the stress and cytokine responses and apoptosis.
These data suggest that Ox-LDL activates N-SMase-ceramide signaling pathway, and stimulates phosphorylation of p38 MAPK (show MAPK14 Proteins), leading to apoptosis in vascular smooth muscle cells, which initiates VSMC calcification.
N-SMase at the cytofacial plasma membrane is an essential element for the proper orientation of PMNs in FMLP (show FPR1 Proteins) gradients, at least in part by polarizing the distribution of Rac 1/2 and RhoA (show RHOA Proteins) GTPases.
Results demonstrate that WithaD enhance the ceramide accumulation by activating N-SMase 2, modulate phosphorylation of the JNK (show MAPK8 Proteins) and p38MAPK (show MAPK14 Proteins) and induced apoptosis in both myeloid and lymphoid cells along with primary cells derived from leukemia patients.
Data show DA remarkably increased the NSMase2 message and protein, whereas little change in NSMase1 and NSMase3 mRNAs.
nSMase2 functions as a growth suppressor in MCF7 cells, linking confluence to the G(0)/G(1) cell cycle check point.
identification of 15 polymorphisms, including 9 novel SNPs, in the SMPD2 gene; one haplotype showed associations with the extrinsic type of atopic dermatitis subgroup
This gene encodes a protein which was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase.
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
, Mg2+-dependent neutral sphingomyelinase
, neutral SMase I
, neutral sphingomyelinase
, sphingomyelin phosphodiesterase 2
, sphingomyelin phosphodiesterase 2-like
, lyso-platelet-activating factor-phospholipase C
, neutral sphingomyelinase 1