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sortilin negatively regulates TGF-beta (show TGFB1 Proteins) signaling by diverting trafficking of precursor proteins to the lysosome during transit through the biosynthetic pathway
Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.
Sortilin has been found to inhibit the conversion of proBDNF into mature BDNF (show BDNF Proteins) by plasmin (show PLG Proteins) and to protect neurons from the apoptotic properties of proBDNF.
Variants near SORT1 is associated with dyslipidemia.
SNPs in SORT1, CETP (show CETP Proteins) and GCKR (show GCKR Proteins) were individually associated with lipid level variations in Algerian population.
The study demostrated that the sortilin deficiency caused by the SORT1 p.G171A mutation may lead to defects in neurotransmission, giving rise to the development of tremor.
Prosaposin (show PSAP Proteins) facilitates sortilin-independent lysosomal trafficking of progranulin (show GRN Proteins).
We conclude that PCSK9 (show PCSK9 Proteins) enhances the degradation of the LDLR (show LDLR Proteins) independently of either APLP2 (show APLP2 Proteins) or sortilin both ex vivo and in mice.
NRH2 enhanced the ratio of Bax (show BAX Proteins)/Bcl-2 (show BCL2 Proteins) by promoting the expressions of proNGF, sortilin and p75NTR (show NGFR Proteins), thereby inducing brain cell apoptosis.
Results show that SORT1 and MYC (show MYC Proteins) SNPs were associated with incident coronary heart disease in African American individuals. We also provide evidence for fine-mapping at this locus, and identified an array wide association for a SNP in MYC (show MYC Proteins).
SORT1 protective allele has a role in attenuated postprandial lipaemia in young adults
Sortilin deficiency induces a beneficial metabolic phenotype in liver and adipose tissue upon DIO, mediated in part by reduced aSMase (show SMPD1 Proteins) activity.
Overexpression of SORT1 was shown to reduce Very-Low-Density Lipoproteins , Triglyceride and Apolipoprotein B (show APOB Proteins) secretion in mice.
sortilin influences cytokine secretion and that targeting sortilin in immune cells attenuates inflammation and reduces atherosclerosis.
Sort1 may play a role in altered hepatic apoB100 (show APOB Proteins) metabolism in insulin (show INS Proteins)-resistant conditions
sigma1B adaptin (show AP1S2 Proteins) regulates adipogenesis by mediating the sorting of sortilin in adipose tissue.
Sortilin-deficient macrophages had significantly reduced uptake of native LDL ex vivo and reduced foam cell formation in vivo, whereas sortilin overexpression in macrophages resulted in increased LDL uptake and foam cell formation.
Sortilin ectopically expressed in undifferentiated cells was translocated to the plasma membrane regardless of the presence or absence of myc7-Glut4 (show SLC2A4 Proteins)
Increased saturated fatty acids downregulate liver Sort1 protein, which may contribute to the development of dyslipidemia in obesity and diabetes.
This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes\; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p\; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins.
, 100 kDa NT receptor
, glycoprotein 95
, neurotensin receptor 3
, glycoprotein 110