Browse our Sortilin 1 Proteins (SORT1)

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Sortilin 1 Proteins (SORT1)
On are 7 Sortilin 1 (SORT1) Proteins from 4 different suppliers available. Additionally we are shipping Sortilin 1 Antibodies (84) and Sortilin 1 Kits (14) and many more products for this protein. A total of 108 Sortilin 1 products are currently listed.
19.m02079, 2900053A11Rik, AI852375, Gp95, LDLCQ6, Nt3, Ntr3, Nts3, Ntsr3, sort1, sortilin, zgc:85953
list all proteins Gene Name GeneID UniProt
SORT1 6272 Q99523
SORT1 20661 Q6PHU5
SORT1 83576 O54861

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Sortilin 1 Proteins (SORT1) by Origin

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More Proteins for Sortilin 1 Interaction Partners

Xenopus laevis Sortilin 1 (SORT1) interaction partners

  1. sortilin negatively regulates TGF-beta (show TGFB1 Proteins) signaling by diverting trafficking of precursor proteins to the lysosome during transit through the biosynthetic pathway

Human Sortilin 1 (SORT1) interaction partners

  1. SORT1 single nucleotide polymorphism and it's association with LDL cholesterol level and risk of coronary heart disease in Pakistani population

  2. Four SNPs within the APOE (show APOE Proteins) cluster (rs7412, rs4420638), ABCC2 (show ABCC2 Proteins) (rs2002042) and CELSR/SORT1/PSRC1 (show PSRC1 Proteins) (rs646776), displayed a major impact on statin efficacy. The wGRS was significantly associated with lower LDL-C at age 75 and 80

  3. In older men, higher serum sortilin levels associated with higher major adverse cerebrovascular/cardiovascular disease risk and severe abdominal aortic calcification.

  4. sortilin is a PIP3 binding protein with binding likely to occur at the C-terminal neurotensin (show NTS Proteins) binding site, and is a competitor of neurotensin (show NTS Proteins)

  5. Focal adhesion kinase-sortilin interactions have an important role in colorectal cancer cells dissociation. (Review)

  6. TDP-43 (show TARDBP PLURAL_@39359@) functions within a network of hnRNP (show HNRNPC PLURAL_@39359@) proteins to inhibit the production of a truncated human SORT1 receptor.

  7. no association was found between the SNPs of rs599839, rs464218 and rs6698843 at the CELSR2 (show CELSR2 Proteins)-PSRC1 (show PSRC1 Proteins)-SORT1 and the risk of coronary artery disease or ischemic stroke

  8. Inverse association between hepatic SORT1 gene expression and hepatic HBsAg expression indicates the possible role of sortilin in HBsAg particle formation.

  9. Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.

  10. Sortilin has been found to inhibit the conversion of proBDNF into mature BDNF (show BDNF Proteins) by plasmin (show PLG Proteins) and to protect neurons from the apoptotic properties of proBDNF.

Mouse (Murine) Sortilin 1 (SORT1) interaction partners

  1. Shh (show SHH Proteins) and Sort1 can interact at the level of the Golgi and that Sort1 directs Shh (show SHH Proteins) away from the pathways that promote its secretion.

  2. By contrast, treatment with dexamethasone, which also induced insulin (show INS Proteins) resistance, was without effect on sortilin expression and PE production. As a putative bioactive peptide, we have evaluated its autocrine effect by the use of spadin on 3T3-L1 adipocytes by performing glucose uptake and signalling experiments. Any effect was measured on adipocytes indicating that the use of spadin as an antidepressant would have no side

  3. Sortilin 1 (Sort1) knockout (KO) does not affect Western diet-induced obesity nor adipose fatty acid and ceramide concentrations.

  4. sortilin regulates cholestatic liver damage and fibrosis via effects on both aSMase (show SMPD1 Proteins) activity and serum IL-6 (show IL6 Proteins).

  5. This study demonstrated that Mice with Sort1 deficiency display normal cognition but elevated anxiety-like behavior.

  6. TDP-43 (show TARDBP PLURAL_@39359@) functions within a network of hnRNP (show HNRNPH2 PLURAL_@39359@) proteins to inhibit the production of a truncated human SORT1 receptor.

  7. Sortilin is highly expressed in epithelial tissues of the developing lung, nasal cavity, kidney, pancreas and salivary gland.

  8. Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.

  9. Sortilin deficiency induces a beneficial metabolic phenotype in liver and adipose tissue upon DIO, mediated in part by reduced aSMase (show SMPD1 Proteins) activity.

  10. Overexpression of SORT1 was shown to reduce Very-Low-Density Lipoproteins , Triglyceride and Apolipoprotein B (show APOB Proteins) secretion in mice.

Sortilin 1 (SORT1) Protein Profile

Protein Summary

This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes\; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p\; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins.

Alternative names and synonyms associated with Sortilin 1 (SORT1)

  • sortilin 1 (SORT1)
  • sortilin (TP01_0016)
  • sortilin (BBOV_I002730)
  • sortilin 1 (sort1)
  • sortilin 1 (Sort1)
  • sortilin 1a (sort1a)
  • 19.m02079 protein
  • 2900053A11Rik protein
  • AI852375 protein
  • Gp95 protein
  • LDLCQ6 protein
  • Nt3 protein
  • Ntr3 protein
  • Nts3 protein
  • Ntsr3 protein
  • sort1 protein
  • sortilin protein
  • zgc:85953 protein

Protein level used designations for Sortilin 1 Proteins (SORT1)

sortilin 1 , sortilin , sortilin-like , 100 kDa NT receptor , NTR3 , glycoprotein 95 , neurotensin receptor 3 , mNTR3 , glycoprotein 110 , gp110

457090 Pan troglodytes
3502711 Theileria parva strain Muguga
5477139 Babesia bovis T2Bo
100158281 Xenopus laevis
100457993 Pongo abelii
6272 Homo sapiens
20661 Mus musculus
83576 Rattus norvegicus
406511 Danio rerio
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