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Browse our Sortilin 1 Proteins (SORT1)

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Sortilin 1 Proteins (SORT1)
On are 6 Sortilin 1 (SORT1) Proteins from 3 different suppliers available. Additionally we are shipping Sortilin 1 Antibodies (82) and Sortilin 1 Kits (10) and many more products for this protein. A total of 100 Sortilin 1 products are currently listed.
19.m02079, 2900053A11Rik, AI852375, Gp95, LDLCQ6, Nt3, Ntr3, Nts3, Ntsr3, sort1, sortilin, zgc:85953
list all proteins Gene Name GeneID UniProt
SORT1 6272 Q99523
SORT1 20661 Q6PHU5
SORT1 83576 O54861

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Sortilin 1 Proteins (SORT1) by Origin

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More Proteins for Sortilin 1 Interaction Partners

Xenopus laevis Sortilin 1 (SORT1) interaction partners

  1. sortilin negatively regulates TGF-beta (show TGFB1 Proteins) signaling by diverting trafficking of precursor proteins to the lysosome during transit through the biosynthetic pathway

Human Sortilin 1 (SORT1) interaction partners

  1. no association was found between the SNPs of rs599839, rs464218 and rs6698843 at the CELSR2 (show CELSR2 Proteins)-PSRC1 (show PSRC1 Proteins)-SORT1 and the risk of coronary artery disease or ischemic stroke

  2. Inverse association between hepatic SORT1 gene expression and hepatic HBsAg expression indicates the possible role of sortilin in HBsAg particle formation.

  3. Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.

  4. Sortilin has been found to inhibit the conversion of proBDNF into mature BDNF (show BDNF Proteins) by plasmin (show PLG Proteins) and to protect neurons from the apoptotic properties of proBDNF.

  5. Variants near SORT1 is associated with dyslipidemia.

  6. SNPs in SORT1, CETP (show CETP Proteins) and GCKR (show GCKR Proteins) were individually associated with lipid level variations in Algerian population.

  7. The study demostrated that the sortilin deficiency caused by the SORT1 p.G171A mutation may lead to defects in neurotransmission, giving rise to the development of tremor.

  8. Prosaposin (show PSAP Proteins) facilitates sortilin-independent lysosomal trafficking of progranulin (show GRN Proteins).

  9. We conclude that PCSK9 (show PCSK9 Proteins) enhances the degradation of the LDLR (show LDLR Proteins) independently of either APLP2 (show APLP2 Proteins) or sortilin both ex vivo and in mice.

  10. NRH2 enhanced the ratio of Bax (show BAX Proteins)/Bcl-2 (show BCL2 Proteins) by promoting the expressions of proNGF, sortilin and p75NTR (show NGFR Proteins), thereby inducing brain cell apoptosis.

Mouse (Murine) Sortilin 1 (SORT1) interaction partners

  1. Sortilin is highly expressed in epithelial tissues of the developing lung, nasal cavity, kidney, pancreas and salivary gland.

  2. Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.

  3. Sortilin deficiency induces a beneficial metabolic phenotype in liver and adipose tissue upon DIO, mediated in part by reduced aSMase (show SMPD1 Proteins) activity.

  4. Overexpression of SORT1 was shown to reduce Very-Low-Density Lipoproteins , Triglyceride and Apolipoprotein B (show APOB Proteins) secretion in mice.

  5. Prosaposin (show PSAP Proteins) facilitates sortilin-independent lysosomal trafficking of progranulin (show GRN Proteins).

  6. sortilin influences cytokine secretion and that targeting sortilin in immune cells attenuates inflammation and reduces atherosclerosis.

  7. Sort1 may play a role in altered hepatic apoB100 (show APOB Proteins) metabolism in insulin (show INS Proteins)-resistant conditions

  8. sigma1B adaptin (show AP1S2 Proteins) regulates adipogenesis by mediating the sorting of sortilin in adipose tissue.

  9. Sortilin-deficient macrophages had significantly reduced uptake of native LDL ex vivo and reduced foam cell formation in vivo, whereas sortilin overexpression in macrophages resulted in increased LDL uptake and foam cell formation.

  10. Sortilin ectopically expressed in undifferentiated cells was translocated to the plasma membrane regardless of the presence or absence of myc7-Glut4 (show SLC2A4 Proteins)

Sortilin 1 (SORT1) Protein Profile

Protein Summary

This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes\; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p\; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins.

Alternative names and synonyms associated with Sortilin 1 (SORT1)

  • sortilin 1 (SORT1)
  • sortilin (TP01_0016)
  • sortilin (BBOV_I002730)
  • sortilin 1 (sort1)
  • sortilin 1 (Sort1)
  • sortilin 1a (sort1a)
  • 19.m02079 protein
  • 2900053A11Rik protein
  • AI852375 protein
  • Gp95 protein
  • LDLCQ6 protein
  • Nt3 protein
  • Ntr3 protein
  • Nts3 protein
  • Ntsr3 protein
  • sort1 protein
  • sortilin protein
  • zgc:85953 protein

Protein level used designations for Sortilin 1 Proteins (SORT1)

sortilin 1 , sortilin , sortilin-like , 100 kDa NT receptor , NTR3 , glycoprotein 95 , neurotensin receptor 3 , mNTR3 , glycoprotein 110 , gp110

457090 Pan troglodytes
3502711 Theileria parva strain Muguga
5477139 Babesia bovis T2Bo
100158281 Xenopus laevis
100457993 Pongo abelii
6272 Homo sapiens
20661 Mus musculus
83576 Rattus norvegicus
406511 Danio rerio
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