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SPG33 protein protrudin contains hydrophobic, intramembrane hairpin domains, interacts with tubular ER proteins, and functions in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections.
findings indicate that protrudin interacts with spastin (show SPAST Proteins) and induces axon formation through its N-terminal domain. Moreover, protrudin and spastin (show SPAST Proteins) may work together to play an indispensable role in motor axon outg
Protrudin-KIF5 com (show KIF5A Proteins)plex contributes to the vesicular trans (show KIF5A Proteins)port in neurons.
protrudin regulates Rab11 (show RAB11A Proteins)-dependent membrane recycling to promote the directional membrane trafficking required for neurite formation [protrudin]
The role of ZFYVE27/protrudin in hereditary spastic paraplegia is reported.
VAP-A (show VAPA Proteins) is an important regulator both of the subcellular localization of protrudin and of its ability to stimulate neurite outgrowth.
Phosphoinositides differentially regulate protrudin localization through the FYVE domain [protrudin]
protrudin contributes to the regulation of ER morphology and function, and that its deregulation by mutation is a causative defect in HSP.
Protrudin and KIF5 (show KIF5A Proteins) interact in mouse brain.Protrudin-KIF5 (show KIF5A Proteins) complex contributes to the vesicular transport in neurons.
This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear.
zinc finger, FYVE domain containing 27
, zinc finger FYVE domain-containing protein 27
, Zinc finger FYVE domain-containing protein 27