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New possibilities for manipulating Notch signalling
The Notch pathway is responsible for the correct development of many tissues and cell types. Recent findings link mutations and/or abnormal signalling of Notch receptors with the onset of human diseases. Therefore, the Notch pathway is a promising therapeutic target. Unfortunately, until recently, there have been no specific inhibitors and/or agonists for human Notch receptors (NOTCH1-4), leaving the potential unexplored. » Read more
17.07.2008 | Anna Lena Marwedel 
Research News
Research NewsNew supplier: Biovision
Biovision antibodies are now listed at antibodies-online.com. »Show Biovision antibodies
17.07.2008 | Tim Hiddemann New Antibodies
New AntibodiesNew supplier: Lifespan antibodies at antibodies-online.com
More than 34.000 Lifespan antibodies are now available at antibodies-online.com. »Show Lifespan-antibodies
17.07.2008 | Tim Hiddemann New Antibodies
New AntibodiesNutritional Control of Reproductive Status in Honeybees via DNA Methylation
Areas: DNA
Silencing the expression of DNA methyltransferase Dnmt3 in newly hatched Apis larvae leads to a royal jelly-like effect on larva development. According to scientists from the Australian National University, the majority of larvae treated with Dnmt3 siRNA grew up to be queens with fully developed ovaries. » Read more
01.07.2008 | Anna Lena Marwedel Research News
Research NewsListeriolysin O allows Listeria monocytogenes replication in macrophage vacuoles
Areas: Bacteria, Immunology
A recent study revealed that Listeria monocytogenes can replicate in the vacuoles within macrophages. Cheryl L. Birmingham and her team from the University of Toronto in Canada observed the localisation of bacteria in large LAMP1+ compartments that they denoted spacious Listeria-containing phagosomes (SLAPs). The SLAPs could also be seen in vitro. They turned out to be non-acidic and non-degradative compartments that are generated in an autophagy-dependent manner. » Read more
01.07.2008 | Anna Lena Marwedel Research News
Research NewsNeurokinin 1 Receptor Antagonism as a Possible Therapy for Alcoholism
A lab group from the National Institutes of Health (USA) investigated the role of neurokinin 1 receptor (NK1R) in alcohol dependence and treatment. NK1R is a mediator of behavioural stress responses and the stress system of the brain and is an important factor for continued alcohol (ab)use and relapse. » Read more
01.07.2008 | Anna Lena Marwedel Research News
Research NewsEndogenous human microRNAs that suppress breast cancer metastasis
A set of microRNAs were discovered to be general regulators of cancer metastasis. Scientist from the Memorial Sloan-Kettering Cancer Center in New York (USA) now demonstrated, how restoring the expression of these microRNAs in malignant cells can suppress lung and bone metastasisation of human cancer cells in vivo. » Read more
01.07.2008 | Anna Lena Marwedel Research News
Research NewsReprogramming of human somatic cells to pluripotency with defined factors
Areas: Transcription Factors
In a recently published study, murine fibroblasts were reprogrammed directly to pluripotency by ectopic expression of the transcription factors Oct4, Sox2, Klf4 and Myc. » Read more
01.07.2008 | Anna Lena Marwedel Research News
Research NewsDefective tryptophan catabolism underlies inflammation in chronic granulomatous disease of mice
Areas: immunology, metabolism
Chronic granulomatous disease (CGD) is an inherited disease, fatally impairing children's ability to survive infections. The cause is a lack of NADPH oxidase activity in the phagocytes that can not generate reactive oxygen species, most notably superoxide anion. Recurring bacterial and fungal infections are the consequences. Patients with CGD also suffer from chronic inflammatory conditions, most prominently granuloma formation in hollow viscera. » Read more
11.06.2008 | Anna Lena Marwedel Research News
Research NewsAssociation of Systemic Lupus Erythematosus with C8orf13-BLK and ITGAM-ITGAX
Areas: DNA, Immunology
Two novel genetic loci associated with risk for systemic lupus erythematosus were found by scientists of the company Genentech. One locus turned out to encode for a promoter-region allele associated with weaker expression of B lymphoid tyrosine kinase and stronger expression of C8orf13 (chromosome 8p23.1). Individuals carrying the risk allele also displayed altered levels of messenger RNA in their B-cell lines. The second locus is on chromosome 16p11.22, close to the gene loci encoding for integrin alpha M (ITGAM, or CD11b) and integrin alpha X (ITGAX). » Read more
11.06.2008 | Anna Lena Marwedel Research News
Research News
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