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Supplier:

Matriks
There are now 384 products available from on the antibodies-online.com platform. is a small enterprise located in Göttingen, Germany. They are specialized in developing antibodies for neuroscientists and cellbiologists.

As the name of the company states, Synaptic Systems' portfolio focuses on antigenes in and around the synapse and neurons, e. g. Amyloid beta (A4) Precursor Protein (APP) antibody. Nevertheless they also offer antibodies of general interest for cellbiologists, e. g.Cortactin antibody or Tubulin, alpha 1B antibody.

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Supplier:

Matriks
There are now 35 products available from on the antibodies-online.com platform. is a small enterprise located in Lansdale, PA, USA. They are specialized in developing assays for biomolecules and drugs. In particular,they produce antibodies and kits to detect Poly(ADP-ribose) and synthetic cannabinoids.

Poly(ADP-ribose) is part of the complex cellular stress response. offers a range of antibodies to detetct Poly(ADP-ribose) Polymerase-1 (PARP1) or pADPR as well as accessory reagents. Furthermore they offer products to detect synthetic canabinoids e. g. K2/spice antibody or JWH-250 (K2/Spice) ELISA kit.

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Supplier:

Matriks
A couple of products from is now available at antibodies-online.com. is a small expanding enterprise located in the USA in Chicago

The company is specialised in developing, manufacturing, and delivering research tools for novel genome-wide sequencing and detection applications. For example: the 5mC Tet1 Oxidation Kit can be used to convert 5-methylcytosine (5mC) to 5-carboxylcytosine (5caC) in genomic DNA, or the 5hmC TAB-Seq Kit can be used to prepare genomic DNA to differentiate between 5-hydroxylmethylcytosine (5hmC) and 5-methylcytosine (5mC) (by converting 5mC to 5-carboxylcytosine (5caC) while keeping 5hmC protected).

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Supplier:

Matriks
There are now 15 products available from on the antibodies-online.com platform. is a small enterprise located in the urban hinterland of Ankara / Turkey. They are specialised in the production of ELISA kits to determine clinical drugs in biological material.

In particular,they produce ELISA kits to detect and quantify angiogenesis inhibitors (like Bevacizumab) or antibodies against CD20 (Rituximab) as those drugs are widely used in the treatment of cancer, as well as inhibitors of tumor-necrosis-faktor α (TNFα), as those are widley used in the threapy of rheumatic diseases and Psoriasis (like (Infliximab, Etanercept and some other).

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Independent Validation

Independent Validation

The antibody for the detection of Dishevelled, Dsh Homolog 1 (Drosophila) (DVL1) has now been successfully validated for immunohistochemistry. A signal was observed in human kidney tubules, while no signal could be detected in human colon stromal tissue.

Dishevelled, Dsh Homolog 1 (Drosophila) (DVL1) participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. It plays a role both in canonical and non-canonical Wnt signaling, and it has a role in the signal transduction pathways mediated by multiple Wnt genes. It is required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
Supplier:

Matriks
There are now 17,455 products available from on the antibodies-online.com platform. seeks to be a socially responsible company that is committed to charitable acts. Their mission is to participate in bioscience progress through supporting the scientific and medical research community by donating charitable organisations, f. e. via a cooperation with Together we can.

We offer a variety of peer-validated polyclonal and monoclonal antibodies mainly focused on human targets, a couple of secondary antibodies mainly capable in Western Blot and ELISA, and a few proteins like sepharose coupled Protein A and G.

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Independent Validation

Independent Validation

The antibody for the detection of Wingless-Type MMTV Integration Site Family Member 2 (WNT2) (N-Term) has now been successfully validated for immunohistochemistry. A signal was observed in human glioma tissue, while no signal could be detected in human brain tissue.

The WNT gene family consists of structurally related genes encoding secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis.

(…) Since last summer Andreas Kessel and Tim Hiddemann from antibodies-online.com support the initiators of Science Exchange. The former spin-off headquartered in Aachen currently delivers more than one million antibodies to laboratories all over the world. It is the task of this cooperation to make antibodies to provide qualitative comparability for antibodies, which are used in biomedical sciences. Scientists and manufacturers can suggest antibodies for validation, which will then be tested in independent laboratories of one of the 1,400 research facilities that build the Science Exchange network. After successful testing the “Independently Validated" label with individual identification number will be granted. This label is intended to be not only a tool for easy validation of scientific studies. Furthermore, with purchase of tested products researchers obtain certainty that antibodies work as it is described in test protocols – and that they are the most suitable choice for the respective question. (...) Source: http://www.spiegel.de/wissenschaft/medizin/qualitaet-der-forschung-rettet-die-wissenschaft-a-959629.html
Independent Validation

Independent Validation

The antibody for the detection of Runt-Related Transcription Factor 3 (RUNX3) has now been successfully validated for immunofluorescence. A strong signal was observed in the human cellline A431 (epidermoid carcinoma), while no signal could be detected in the isotype staining and staining of HEK293 cells.

A complex formed of a heterodimer of Runt-Related Transcription Factor 3 (RUNX3) and a beta subunit binds to the core DNA sequence 5'-YGYGGT-3' found in a number of enhancers and promoters. That can either activate or suppress transcription. RUNX3 can also interact with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer.

Independent Validation
Under the title "The Antibody Challenge" Jeffrey M. Perkel wrote in BioTechniques (BioTechniques, March 2014, pp. 111-114) about the issues of reproducibility. In his interesting article he also described the independent validation initiative and interviewed our collegue Stefan Pellenz, who runs the validation initiative at antibodies-online: "Recently, Iorns launched a new effort to help. In collaboration with antibody distributor antibodies-online.com, the ScienceExchange Independent Validation Initiative pairs vendors with independent labs that can provide third-party validation of antibody efficacy for several hundred dollars per test.

The initiative kicked off in July 2013 but has only gained traction in the past few months, says Iorns. “We've done hundreds of tests so far, and we're planning to do 10,000 this year.”

Successfully validated antibodies are awarded a green check mark “badge” for the vendor's web site. “We are trying to establish this as kind of a sign of quality,” says Stefan Pellenz, who runs the validation initiative at antibodies-online. But companies gain more from the process than just a logo, he adds; it is also a marketing tool, conveying to users that their reagent vendors take quality control seriously. Furthermore, the validating labs can work with the vendor (via Science Exchange) for troubleshooting. In one case, an ELISA kit shipped with a bad dilution buffer that was masking the target protein signal. Once the lab figured that out and reported it back to the vendor, the kit was updated subsequently passed validation “with flying colors,” Pellenz says.
Independent Validation

Independent Validation

The antibody for the detection of Prostate Specific Antigen (PSA) has now been successfully validated for flow cytometry. A strong signal was observed in the androgen-sensitive human prostate adenocarcinoma cellline LNCaP. The peak is clearly separated from the isotype stained probe.

Prostate Specific Antigen (PSA) is a typical serine protease with Semenogelin-1 as its substrate. The cleavage of Semenogelin-1 liquefies the seiminal fluid. PSA is a tissue-specific biomarker and not a general marker for prostate cancer. PSA is present in small quantities in the serum of men with healthy prostates, but is often elevated in the presence of prostate cancer or other prostate disorders. Increased levels of PSA can be indicative of prostate cancer.
Independent Validation

Independent Validation

The antibody for the detection of Cadherin 5 (CDH5) has now been successfully validated for immunofluorescence. A clear signal of the calcium-depending adhesion molecule was achieved in murine liver tissue while murine brain tissue (known to be negative for cadherin 5) remained unstained.

Cadherin 5 (also called CD144) is a vascular endothelial cadherin. This type of cadherins appears at the contact site of endothelial cells. They are functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, and additional they fundction also as a desmosome.
Supplier:

Spring Bioscience
There are now more than 2,600 products available from on the antibodies-online.com platform. The strategy of Spring Bioscience is to develop a carefully selected portfolio of products that will provide both the research and diagnostic communities with strategic antibody biomarkers for assessing protein expression in tissue. Spring Bioscience complements these antibody products with an elegant selection of advanced detection and ancillary products that are useful in the field of immunohistochemistry (IHC). Spring Bioscience further developed the production of monoclonal antibodies from rabbit. The most famous rabbit monoclonal antibody is the actual gold standard for detection of the Estrogen Receptor 1 (ESR1) in IHC. Browse through all products.

Image for Cytokeratin 1-19 (pan-) antibody
  • Their purpose is to function as a barrier, protecting the body from mechanical damage, invading micro organisms and the loss of body fluids.
  • Detection of epithelial cells has a central role in research on cancer diseases.
  • A range of antibodies has been established for detection of individual epithelial cells.
  • Some standard markers are: anti-epithelial membrane antigen (EMA) antibody and pan-cytokeratin antibody
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