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HMGB1 proteins and antibodies

HMGBiotech is a biotech company which provides, for example, proteins and primary antibodies in the HMGB field.

High-mobility group protein B1 (HMGB1), also known as high-mobility group protein 1 (HMG-1) and amphoterin is a component of the cell nucleus, with various roles in the organization and expression of the genome.

Unacetylated HMGB1 stays in the nucleus but its hyperacetylation (on lysines) causes its translocation into the cytosol. In the nucleus, HMGB1 can bind and bend the DNA, which facilitates transcription factor binding. It can also help in stabilizing nucleosome formation. Outside the cell it is an important cytokine that mediates the response to infection, injury and inflammation.