The host protein calprotectin has now been identified as a neutrophil-dependent factor expressed inside Staphylococcus aureus abscesses by scientists from the Vanderbilt University (USA). Calprotectin derived from neutrophils inhibited growth of S. aureus by chelation of the nutrients Mn2+ and Zn2+. This reaction reprograms the bacterial trancriptome.

Abcesses are a frequent consequence of bacterial infection and the main site of interaction between invading bacteria and the host's innate immune system. The scientists analysed abscesses of mice lacking calprotectin. They turned out to be enriched in metal while the proliferation of staphylococcus was increased in this metal-rich environment. Metal chelation therefore proofs to be a successful strategy to inhibit microbial growth inside abscessed tissue.

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Staphylococcus aureus

Calprotectin (Makrophage L1-Protein)

Neutrophils

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