The immortalized cell lines, which were generated by scientists of the University of Uppsala (Sweden) of the Queen Mary University (London, UK), proved to be valuable models for testing therapeutic approaches against Epidermolysis bullosa simplex (EBS). Note: These antibodies were used for this publication: Cytokeratin 1 (KRT1,AE1) antibody, Cytokeratin 5 (KRT5, XM26) antibody, Cytokeratin 6 (KRT6, LHK6B) antibody, Cytokeratin 10 (KRT10, DE-K10) antibody und Cytokeratin 14 (KRT14, LL002) antibody.

EBS is a heridatry skin disease, which stems from mutations in Cytokeratin 5 or Cytokeratin 14 genes.