DNA: Detection of Thymine Dimer

Area: DNA, Cancer

Thymine (5-Methyluracil) is one of the four bases in the nucleic acid of DNA. Thymine Dimer are covalent bondings between adjacent thymine residues. These bondings are triggered by UV light rays for example. For detecting Thymine Dimer this anti-Thymine Dimer antibody (Clone KTM53) is being used in numerous current publications. Depending on the application the antibody is also employed as a HRP conjugate. Here you may find the most current publications, in which the use of anti-Thymine Dimer antibody is cited:

Publication	Application
Luis F.Z. Batista et al - p53 Mutant Human Glioma Cells Are Sensitive to UV-C-Induced Apoptosis Due to Impaired Cyclobutane Pyrimidine Dimer Removal - Mol Cancer Res February 1, 2009 7, 237	Dot Blot Analyse (1:1000)
D. Bacqueville et al - Comparative analysis of solar radiation-induced cellular damage between ex vivo porcine skin organ culture and in vitro reconstructed human epidermis - International Journal of Cosmetic Science. Published Online: 20 May 2009	Immunohistochemistry (1:60)
VV da Silva et al - Photoprotective effect of Pothomorphe umbellata on UVB radiation-induced biomarkers involved in carcinogenesis of hairless mouse epidermis - Cutan Ocul Toxicol. 2009 Mar 13:1-7. [Epub ahead of print]	Immunohistochemistry (1:100)
M. S. Ke et al - UV Protective Effects of DNA Repair Enzymes and RNA Lotion - Photochemistry and Photobiology. Volume 84 Issue 1, Pages 180 - 184	Immunohistochemistry (1:100)
T. Gambichler et al - Tacrolimus ointment neither blocks ultraviolet B nor affects expression of thymine dimers and p53 in human skin - Journal of Dermatological Science, Volume 50, Issue 2, Pages 115-122	-
TI Ellison et al - Inactivation of the vitamin D receptor enhances susceptibility of murine skin to UV-induced tumorigenesis - J Invest Dermatol. 2008 Oct;128(10):2508-17	-