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Detection of P-Glycoprotein (MDR-1, ABCB1)

P-Glycoprotein (MDR-1, ABCB1) belongs to the group of Multidrug Resistant Proteins. These proteins impede the absorption of drugs and promote the resistance against anti-cancer drugs. For detecting P-Glycoprotein (MDR-1, ABCB1) this monoclonal anti-P-Glycoprotein antibody (Clone MRK16) is being used increasingly: anti-Human P-Glycoprotein antibody (ABIN187222). The antibody has been tested in flow cytometry, in immunohistochemistry with frozen sections and in immunofluorescence. Take a look at the latest publications, in which anti-P-Glycoprotein antibody has been employed:
Publication Application
Brown CD et al. (2008) Characterisation of human tubular cell monolayers as a model of proximal tubular xenobiotic handling. Toxicol Appl Pharmacol. 2008 Dec 15;233(3):428-38. »Show publication Immunofluorescence (1:20)
Camera et al. (2009) Sequential continuous infusion of fludarabine and cytarabine associated with liposomal daunorubicin (DaunoXome) (FLAD) in primary refractory or relapsed adult acute myeloid leukemia patients. Ann Hematol. 2009 Feb;88(2):151-8. »Show publication Flow Cytometry (FACS)
Candoni A. et al (2008) Gemtuzumab-ozogamicin in combination with fludarabine, cytarabine, idarubicin (FLAI-GO) as induction therapy in CD33-positive AML patients younger than 65 years. Leuk Res. 2008 Dec;32(12):1800-8. »Show publication Flow Cytometry (FACS)
Simon J. Crabb. (2008) Characterisation of the in vitro activity of the depsipeptide histone deacetylase inhibitor spiruchostatin A. Biochemical Pharmacology, Volume 76, Issue 4, 15 August 2008, Pages 463-475. »Show publication Flow Cytometry (FACS)
de Figueiredo-Pontes LL et al (2008) Determination of P-glycoprotein, MDR-related protein 1, breast cancer resistance protein, and lung-resistance protein expression in leukemic stem cells of acute myeloid leukemia. Cytometry B Clin Cytom. 2008 May;74(3):163-8. »Show publication Flow Cytometry (FACS)
Jason M. Gow et al. (2008) The Effects of ABCB1 3'-Untranslated Region Variants on mRNA Stability. Drug Metabolism and Disposition Fast Forward. 2008 Jan;36(1):10-5. »Show publication -
Gow J. et al. (2008) Substrate-Dependent Effects of Human ABCB1 Coding Polymorphisms. J Pharmacol Exp Ther. 2008 May; 325(2): 435–442. »Show publication Flow Cytometry (FACS)
María Fabiana De Rosa et al. (2008) Inhibition of Multidrug Resistance by AdamantylGb3, a Globotriaosylceramide Analog. J. Biol. Chem., Vol. 283, Issue 8, 4501-4511, February 22, 2008. »Show publication Immunohistochemistry (10 µg/ml)
Scheidemann F. et al. (2008) The skin as a biofactory for systemic secretion of erythropoietin: potential of genetically modified keratinocytes and fibroblasts. Experimental Dermatology Volume 17, Issue 6, Pages 481-488»Show publication Flow Cytometry (FACS)
Yang Z. et al. (2008) A novel human multidrug resistance gene MDR1 variant G571A (G191R) modulates cancer drug resistance and efflux transport. J Pharmacol Exp Ther. 2008 Nov;327(2):474-81. »Show publication -

Take a look at the antibody, which has been used in the publications listed above: anti-Human P-Glycoprotein antibody (ABIN187222).