Proliferating cell nuclear antigen (PCNA) plays a key role in DNA replication, repair, cell cycle regulation, and post-replicative transactions like DNA methylation and chromatin remodeling. It is an essential cellular component, originally characterized as playing an important role in dividing cells. PCNA is evolutionary highly conserved from yeast to human.

All these cellular processes are regulated by a complex network comprising cell cycle dependent changes in expression levels, dynamics, interactions, and localization of PCNA. This monoclonal antibody (MAb) raised in rats is specific against human PCNA, and, due to the highly conserved sequence, also against several other species. PCNA is a highly affine and specific MAb suited for ELISA, Western Blotting, immunoprecipitation, and immunofluorescence.

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