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TRAIL-Receptor 1: mediator of apopotic responses

The transmembrane receptor is a member of the TNF family and is being expressed in most human tissues. has also been denominated death receptor (DR) 4 which derives from the pro-apoptotic action exhibits.

Apoptosis is activated by the ligand and has been shown to interact with the . Additionally, (FADD) mediated apoptosis has been shown to be mediated via based signal transduction. This anti-human TRAIL-R1 antibody can be used in flow cytometry, immunoprecipitation, immunocytochemistry and functional applications and is a fusion protein containing the extracellular part of and the constant part of the heavy chain of the human IgG1.

This antibody has recently been published: »Show datasheet
Source: Simova S, Klima M, Cermak L, Sourkova V, Andera L: Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane. Apoptosis. 2008 Mar;13(3):423-36.
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