The transmembrane receptor TRAIL-R1
is a member of the TNF family and is being expressed in most human tissues. TRAIL-R1
has also been denominated death receptor (DR) 4 which derives from the pro-apoptotic action TRAIL-R1exhibits.
Apoptosis is activated by the ligand TRAIL
has been shown to interact with the Death Associated Protein 3 (DAP3)
. Additionally, FAS-Associated Protein with Death Domain (FADD) mediated apoptosis has been shown to be mediated via TRAIL-R1
based signal transduction. Discover all TRAIL-R1
antibodies and their different capabilities in flow cytometry, immunoprecipitation, immunocytochemistry and functional applications