AMPK alpha-2 (PRKAA2) or shortened AMPK2 is a catalytic subunit of the heterotrimer AMP-activated protein kinase (AMPK). Studies have suggested that the AMPK2 subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. antibodies-online.com offers a versatile AMPK2-antibody that has recently been successfully tested for Western Blotting with human material.

AMPK is an important energy-sensing enzyme, often described as having a gauge-like function that monitors cellular energy status. In response to cellular metabolic stresses (energy deprivation, hypoxia etc.), AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. AMPK2 hence has been intensely studied in the context of Type 2 Diabetes Mellitus and other metabolic disorders.

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