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New: Antibodies and Research Tools for Allergy Research

Area: Immunology, Allergy

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Immunoglobulin E (IgE), and the interaction with it’s receptors expressed on mast cells and basophils, are main players in the pathomechanism of IgE mediated allergic reactions (allergic rhinitis, asthma, atopic dermatitis, food allergies). Purified human IgE protein, recombinant IgE receptors, and biochemically and functionally well characterized monoclonal antibodies, directed against different epitopes on these players, are tools of central importance for allergy research and diagnostics, and also for the identification and development of novel anti-allergic drugs.

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19.03.2010 | David Kitz Kramer   RSS Feed   New Antibodies  

TRAIL-Receptor 1: mediator of apopotic responses

Area: Apoptosis
Image: ABIN94303
The transmembrane receptor TRAIL-R1 is a member of the TNF family and is being expressed in most human tissues. TRAIL-R1 has also been denominated death receptor (DR) 4 which derives from the pro-apoptotic action TRAIL-R1 exhibits.  » Read more
19.03.2010 | David Kitz Kramer   RSS Feed   New Antibodies  

Aseptic Surgery Forum 2010

The international congress Aseptic Surgery Forum 2010 focuses on the prevention and treatment of post-surgical infections.
The first edition of the meeting will be held on March 26 and 27 in Paris (France). It is aimed at promoting good surgical practices and technological innovations to cure and prevent post-surgical complications.  » Read more
18.03.2010 | David Kitz Kramer   RSS Feed   New Antibodies  

Bax: antibody against pro-apoptotic marker

Area: Apoptosis
Bax can form homodimers, and also heterodimerizes with Bcl-2 and Bcl-XL proteins. This is possible because Bax is a member of the Bcl-2 family of apoptosis-associated proteins. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment.  » Read more
18.03.2010 | David Kitz Kramer   RSS Feed   New Antibodies  

Forkhead box protein N1 (FOXN1) antibody: key gene in human development

Area: Cancer, Metabolism
Image for ABIN185069
The forkhead (named after the Drosophila melanogaster gene fork head) gene family comprises a diverse group of 'winged-helix' (called after its butterfly-like shape) transcription factors that play important roles in development, metabolism, cancer, ageing and speech development in humans.  » Read more
16.03.2010 | David Kitz Kramer   RSS Feed   New Antibodies  

Cancer diagnostics research: anti-Mitotic cells antibody

Area: Chromatin, Cancer
Image: ABIN335393
The cell cycle of eukaryotic cells consists of various phases. Two of them can be identified morphologically and biochemically. The first phase that can be distinguished happens during cell mitosis (M-phase), in which the cell divides into two identical daughter cells; chromosome condensation and spindle formation are microscopically visible. The second discernible phase is the S-phase where the DNA of a cell is replicated. Antibodies recognizing the phases of the cell cycle are of value for example in cancer research.  » Read more
11.03.2010 | David Kitz Kramer   RSS Feed   New Antibodies  

Broadly applicable: Nitro Tyrosine Antibody

Area: Protein Modifications
Image: ABIN308216
Tyrosine nitration is a posttranslational modification generated by a nitrogen free radical (peroxinitrite ONOO-). This reactive nitrogen specie reacts with macromolecules of the organism and alters their functions. This modification can lead to cell death during cell-stress conditions. Nitration is involved in many signalling pathways and plays a role in diverse research-areas ranging from Alzheimer's Disease over Immunology to Virology.  » Read more
11.03.2010 | David Kitz Kramer   RSS Feed   New Antibodies  

Frequently cited: Antibody detects antibacterial protein Cathelicidin

Area: Bacteria
Image: ABIN350187
Cathelicidin acts as effector of the innate immune system and possesses antimicrobial and immunomodulatory functions. Cathelicidin binds to bacterial lipopolysaccharides, and hence serves a critical role in the mammalian immune defence against bacterial infection. These peptides have been isolated from several species of mammals, and are part of a family of proteins situated in specific granules of polymorphonuclear leukocytes.  » Read more
11.03.2010 | David Kitz Kramer   RSS Feed   New Antibodies  

New research-area: Autophagy

Autophagy is a cell-function that takes care of destruction and recycling of cell components. Thereby autophagy assures a balance between synthesis and catalysis of cell components. Autophagy is also part of the immune response, and belongs to the innate immune system. Malfunctions of autophagy can lead to development of various diseases. Now antibodies-online.com offers more than 140 antibodies for research in the field of autophagy.
10.03.2010 | David Kitz Kramer   RSS Feed   New Antibodies  

New antibody: Enhanced Green Fluorescent Protein (EGFP) antibody

Area: Bacteria
Image: EGFP antibody in western blot application
The Enhanced Green Fluorescent Protein (EGFP) is a 29 kDa recombinant protein that emits fluorescent light of a wavelength of 488/507 nm. This Protein A purified rabbit polyclonal antibody detects EGFP and is specifically suitable for western blotting applications. In the 1960s and 1970s GFP was first purified from Aequorea victoria. It was not until the early 1990s that molecular biologists succeeded in utilizing wtGFP as a tool with multiple applications in genetics and molecular biology. EGFP has been optimized for brighter fluorescence and expression in mammalian cells.

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09.03.2010 | David Kitz Kramer   RSS Feed   New Antibodies