DUBA: A Deubiquitinase that Regulates Type I Interferon Production

The Deubiquitinating Enzyme A (DUBA) turns out to be a negative regulator of innate immune responses. A recent study conducted by N. Kayagaki from the biotech business firm Genentech (USA) discovered the deubiquitinating enzyme with the ovarian tumor domain as regulator of IFN type 1 production, which is a crucial host defense, caused by pattern-recognition receptors (PRRs) of the innate immune system.

A reduction of DUBA increased the PRR-induced IFN type 1 (IFN-1) response. DUBA was also found to bind TRAF3, an E3 ubiquitin ligase and essential for the IFN-1 response. DUBA cleaved TRAF3 which led to the dissociation of the protein from the signalling complex containing TANK-binding kinase 1. DUBA efficiently deubiquitinates TRAF3 and hence suppresses IFN-1.

Related antibodies at antibodies-online.com:

Type 1 Interferons:

Interferon-alpha
Interferon-beta
Interferon-omega

TRAF3 (tumor necrosis factor receptor-associated factor 3)

TANK / Tankyrase

TANK-1

DUB3

Ubiquitin

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