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Regulation of Replication Fork Progression Through Histone Supply and Demand
Research areas: DNA
Asf1 seems to be a provider of fine-tuned progression of the replication fork during DNA replication and histone supply and demand. The chaperone is a histone acceptor and donor and handles parental and new histones at the replication fork through an Asf1-(H3-H4)-MCM2-7 intermediate, state Anja Grot and her team from the Institute Curie in France.
Histone dynamics and their coordination in concert with fork progression to maintain chromosome stability have been undiscovered so far. Now the team from France and Denmark describes a complex, connecting the human chaperone Asf1 and replicative helicase MCM2-7 via a histone H3-H4 bridge.
The scientists depleted Asf1 and observed impeded DNA unwinding at the replication sites. Overproduction of new histones H3-H4, which impair Asf1 function, led to similar effects.
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08.01.2008 | Anna Lena Marwedel 
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