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Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin

The nucleus reformation during mitosis is stimulated by hexameric that inactivates the chromatin-associated kinase . Kristijan Ramadan and Roland Bruderer from the ETH in Zurich, Switzerland, observed to inhibit nucleus reformation by preventing decondensation of the chromosomes and arrangement of a nuclear double-membrane around the chromatin, two processes required for nucleus reformation.

On exit of mitosis, binds to and removes it from the chromatin. thus becomes inactivated and chromatin decondensation and nuclear membrane formation can take place. Protein extraction is apparently a common mechanism of Cdc48/ activity in nucleus reformation.

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