BASKET
HELP
News
CLOCK-mediated acetylation of BMAL1 controls circadian function
CLOCK, a protein that regulates circadian rhythm, also acetylates its partner protein, BMAL1 on a unique, highly conserved Lys 537 residue, as a recent study by Jun Hirayama from the University of California (USA) shows.
CLOCK, a protein that regulates circadian rhythm, also acetylates its partner protein, BMAL1 on a unique, highly conserved Lys 537 residue, as a recent study by Jun Hirayama from the University of California (USA) shows.
The CLOCK-BMAL1 complex is responsible for activating CLOCK-controlled genes, like cryptochromes (Crys). The gene products directly repress CLOCK-BMAL1.
The scientists discovered that BMAL1 undergoes rhythmic acetylation in murine liver tissue. The timing was observed to parallel the circadian transcriptional downregulation of CLOCK-controlled genes. The BMAL1 acetylation supports transcriptional repression by facilitating the recruitment of CRY1 to CLOCK-BMAL1 complexes.
Ectopic expression of mutated BMAL1 (K537R-mutation) cannot rescue circadian rhythmicity in vitro. The circadian machinery therefore requires the enzymatic interaction of two CLOCK core components.
Related antibodies on antibodies-online.com:
29.01.2008 | Anna Lena Marwedel 
Research News
Research News
More Headlines: Research News
- 09.10.2008 Autophagy Is Essential for Preimplantation Development of Mouse Embryos
- 09.10.2008 Modulation of Gene Expression via Disruption of NF-kappa-B Signaling by a Bacterial Small Molecule
- 09.10.2008 Anomalous Type 17 Response to Viral Infection by CD8+ T Cells Lacking T-bet and Eomesodermin
- 26.09.2008 Eco1-Dependent Cohesin Acetylation During Establishment of Sister Chromatid Cohesion
- 26.09.2008 Identifying Autism Loci and Genes by Tracing Recent Shared Ancestry
- 26.09.2008 Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons
- 11.09.2008 Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independent of Pax5
- 11.09.2008 Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer
- 11.09.2008 CD160 inhibits activation of human CD4+ T cells through interaction with herpes virus entry mediator
- 27.08.2008 Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes
- 27.08.2008 Molecular dissection of NRG1-ERBB4 signaling implicates PTPRZ1 as a potential schizophrenia susceptibility gene
- 27.08.2008 Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice
- 11.08.2008 Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone
- 11.08.2008 Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-big gamma phosphorylation
- 11.08.2008 Breast milk-mediated transfer of antigens induces tolerance and protection from allergic asthma
- 30.07.2008 Evidence for Editing of Human Papillomavirus DNA by APOBEC3 in Benign and Precancerous Lesions
- 30.07.2008 An Agonist of Toll-Like Receptor 5 Has Radioprotective Activity in Mouse and Primate Models
- 29.07.2008 Monoclonal Antibodies produced by Plants - an Update on Plantal Genepharming
- 29.07.2008 A new Light on Plant Metabolism
- 17.07.2008 New possibilities for manipulating Notch signalling
- 01.07.2008 Nutritional Control of Reproductive Status in Honeybees via DNA Methylation
- 01.07.2008 Listeriolysin O allows Listeria monocytogenes replication in macrophage vacuoles
- 01.07.2008 Neurokinin 1 Receptor Antagonism as a Possible Therapy for Alcoholism
- 01.07.2008 Endogenous human microRNAs that suppress breast cancer metastasis
- 01.07.2008 Reprogramming of human somatic cells to pluripotency with defined factors
- 11.06.2008 Defective tryptophan catabolism underlies inflammation in chronic granulomatous disease of mice
- 11.06.2008 Association of Systemic Lupus Erythematosus with C8orf13-BLK and ITGAM-ITGAX
- 11.06.2008 A Shared Docking Motif in TRF1 and TRF2 Used for Differential Recruitment of Telomeric Proteins
- 11.06.2008 Spine-Type-Specific Recruitment of Newly Synthesized AMPA Receptors with Learning
- 11.06.2008 Semaphorin and neuropilin co-expression in motoneuronssets axon sensitivity to environmental semaphorin sources during motor axon pathfinding
- 20.05.2008 Hepatitis E Virus and Chronic Hepatitis in Organ Transplant Recipients
- 20.05.2008 Hepatic Glucose Sensing via the CREB Coactivator CRTC2
- 14.05.2008 Dual role of proapoptotic BAD in insulin secretion and beta cell survival
- 14.05.2008 Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cells
- 05.05.2008 A Heme Export Protein Is Required for Red Blood Cell Differentiation and Iron Homeostasis
- 05.05.2008 Repression of the Transcription Factor Th-POK by Runx Complexes in Cytotoxic T- Cell Development
- 05.05.2008 Reciprocal Binding of PARP-1 and Histone H1 at Promoters Specifies Transcriptional Outcomes
- 17.04.2008 Systemic Leukocyte-Directed siRNA Delivery reveals Cyclin D1 as an Anti-Inflammatory Target
- 17.04.2008 Cathepsin K-Dependent Toll-Like Receptor 9 Signaling Revealed in Experimental Arthritis
- 17.04.2008 Plexin-B1 mutations in prostate cancer
- 17.04.2008 Recognition of an Ubiquitous Self Antigen by Prostate Cancer-Infiltrating CD8+ T Lymphocytes
- 08.04.2008 Initiating and Cancer-Propagating Cells in TEL-AML1-Associated Childhood Leukemia
- 08.04.2008 Lhx2 Selector Activity Specifies Cortical Identity and Suppresses Hippocampal Organiser Fate
- 08.04.2008 Dendritic Cell-Induced Memory T Cell Activation in Nonlymphoid Tissues
- 31.03.2008 DNA Oxidation is Triggered by H3K9me2 Demethylation and Drives Estrogen-Induced Gene Expression
- 31.03.2008 Heterochromatin and RNAi Are Required to Establish CENP-A Chromatin at Centromeres
- 26.03.2008 The inhibitory cytokine IL-35 contributes to regulatory T-cell function
- 26.03.2008 An antidepressant that extends lifespan in adult Caenorhabditis elegans
- 26.03.2008 Expression of CFTR from a ciliated cell-specific promoter is ineffective at correcting nasal potential difference in CF mice
- 26.03.2008 In vivo splenic CD11c cells downregulate CD4 T-cell response thereby decreasing systemic immunity to gene-modified tumour cell vaccine
- 10.03.2008 Endothelin B receptor mediates the endothelial barrier to T cell homing to tumours and disables immune therapy
- 10.03.2008 Modification of kidney barrier function by the urokinase receptor
- 10.03.2008 Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge
- 10.03.2008 NFAT Binding and Regulation of T Cell Activation by the Cytoplasmic Scaffolding Homer Proteins
- 20.02.2008 Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease
- 11.02.2008 Circulation: Connection between ancient protein of cold shock family and cardiovascular disease
- 29.01.2008 Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses
- 29.01.2008 The contribution of transcription factor IRF1 to the interferon-big gamma-interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells
- 29.01.2008 Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin
- 29.01.2008 Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis
- 16.01.2008 Kidney International: Role of YB-1 in chronic kidney disease
- 08.01.2008 Regulation of Replication Fork Progression Through Histone Supply and Demand
- 08.01.2008 DUBA: A Deubiquitinase that Regulates Type I Interferon Production
- 08.01.2008 Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase
- 12.02.2007 Fighting fire with fire: Virus-like Vaccine against Influenza Virus
- 12.02.2007 Studying the effect of Cox-2 inhibitors on upper gastrointestinal events
- 12.02.2007 Cyclic AMP levels and neurite outgrowth promoted by G protein-coupled receptors
- 13.01.2007 Generation of high-affinity monoclonal antibodies via genetic immunization
browse antibodies by
Antigens
Secondary Antibodies
Research areas
Clones
Hosts
Applications
Reactivity
Supplier
Antigens
Secondary Antibodies
Research areas
Clones
Hosts
Applications
Reactivity
Supplier