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The contribution of transcription factor IRF1 to the interferon-big gamma-interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells

and usually power T helper cell type 1 differentiation. The -induced transcription factor seems to be essential in T helper cell type 1 differentiation by acting on , the gene encoding for the beta1 subunit of the (). This was reported by Shin-ichi Kano and collaborators from the University of Tokyo. According to their research, interacts directly with the promoter in and activates it.

Recent evidence reveals that the -dependent initiation of was crucial for - signalling. It was not required for - signalling. Since as well as bind and transmit signals through , the scientists propose that clear thresholds of expression are essential for T helper cell type 1 versus T helper cell type 17 differentiation.

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