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NFAT Binding and Regulation of T Cell Activation by the Cytoplasmic Scaffolding Homer Proteins
Areas: Immunology, Signalling
Homer2 and Homer3, two cytoplasmic scaffolding proteins hinder T-cell activation. T-cells are activated by T-cell receptor (TCR) and costimulatory receptor (CD28) signals. This process is inhibited by binding of NFAT (nuclear factor of activated T cells) and by competing with calcineurin.
The active serine-threonine kinase AKT counteracts against the Homer-NFAT binding. The kinase enhances TCR signalling by dephosphorylating NFAT in a calcineurin-dependent reaction.
Homer-deficient mice developed autoimmune-like pathology. Their cytokine expression was altered and their effector-memory T-cell populations elevated.
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10.03.2008 | Anna Lena Marwedel 
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