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Cyclic AMP levels and neurite outgrowth promoted by G protein-coupled receptors
GPR3, GPR6, and GPR12
belong to a family of active G protein-coupled receptors (GPCRs)
which share a high similarity at the amino acid level.
The GPCRs are highly expressed in the central nervous system.
cAMP production is stimulated by their expression in various cell lines.
As Tanaka et al show in their current study that constitutively active GPCRs enhance neurite outgrowth when they are overexpressed
in rat cerebellar granule neurons in culture. Thereby GPCRs help to overcome growth inhibition caused by myelin-associated glycoprotein (MAG).
The authors conclude that expression of the constitutively active GPCRs upregulates cAMP production in neurons, stimulates neurite outgrowth and counteracts myelin inhibition.
The following antibodies for this topic are available at antibodies-online.com:
Antibodies against G-protein coupled receptors (GPR AGR9 to GPR87/95)
Antibodies against G-protein coupled receptors (GPR88 to GPR TM7XN1)
Antibodies for the research area "Signaling": Show antibodies
Antibodies for the research area "Receptors": Show antibodies
12.02.2007 | Tim Hiddemann 
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